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H and 13C N M R spectra for the four carthartic constituents of Cascara bark, namely, the cascarosides A-D are recorded. The conformation and absolute configuration of each component of the two diastereoisomeric pairs have been determined on the basis of anisotropic effects and specific NOE (nuclear Overhauser effects) in their l H NMR spectra. CD spectra for these anthrone C, 0 -dig I ucosides are reported. Cascara bark (Rhamnus purshianus DC bark), a well known carthartic drug,2 has been shown to contain barbaloin l 3 (as a mixture of two C-10 diastereoisomers called aloin A and B),4 1 1 -deoxybarbaloin 2,5 for which the name chrysaloin has been proposed,6 10-hydroxyaloins A and B 3,7 and two pairs of diastereoisomeric 0, C-diglucosides, i. e. cascarosides A, B q8*' and C, D 5. l o The constitution of cascarosides has been clarified by Fairbairn and his colleagues 'vl '-' and by Wagner and Paper 3/01623D

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Thirty-two 3-phenyl-l-monosubstituted(or 1 ,l-disubstituted)prop-2-yn-l-ols, mostly with heterocyclic substituents, and four derivatives, were synthesised and tested in vivo against eight fungal plant pathogens of different taxonomic classes. No compound showed a wide spectrum of activity, however, nine of them were effective against Sphaerotheca jidiginea on Cucumis sativus, both in direct protectant tests and in systemic protectant tests by root application.