We demonstrate a swift ion-beam irradiation procedure based on electronic (not nuclear) excitation to generate a large index jump step-like optical waveguide (Δn0≈0.2,Δne≈0.1) in LiNbO3. The method uses medium-mass ions with a kinetic energy high enough to assure that their electronic stopping power Se(z) reaches a maximum value close to the amorphous (latent) track threshold inside the crystal. Fluorine ions of 20 and 22MeV and fluences in the range (1–30)×1014 are used for this work. A buried amorphous layer having a low refractive index (2.10 at a wavelength of 633nm) is then generated at a controlled depth in LiNbO3, whose thickness is also tuned by irradiation fluence. The layer left at the surface remains crystalline and constitutes the core of the optical waveguide which, moreover, is several microns far from the end of the ion range. The waveguides show, after annealing at 300°C, low propagation losses (≈1dB∕cm) and a high second-harmonic generation coefficient (50%–80% of that for bulk unirradiated LiNbO3, depending on the fluence). The formation and structure of the amorphous layer has been monitored by additional Rutherford backscattering/channeling experiments.
The operation of photovoltaic (PV) tweezers, using the evanescent light-induced PV fields to trap and pattern nano- and micro-meter particles on a LiNbO(3) crystal surface, is discussed. The case of a periodic light pattern is addressed in detail, including the role of particle shape and the modulation index of the light pattern. The use of a single Gaussian light beam is also considered. Illustrative experiments for the two situations are presented. The performance of such PV tweezers in comparison to the best established case of optical tweezers, using optical forces, is considered. Differential features between the two trapping approaches are remarked.
The application of evanescent photovoltaic (PV) fields, generated by visible illumination of Fe:LiNbO 3 substrates, for parallel massive trapping and manipulation of micro-and nano-objects is critically reviewed. The technique has been often referred to as photovoltaic or photorefractive tweezers. The main advantage of the new method is that the involved electrophoretic and/or dielectrophoretic forces do not require any electrodes and large scale manipulation of nano-objects can be easily achieved using the patterning capabilities of light. The paper describes the experimental techniques for particle trapping and the main reported experimental results obtained with a variety of micro-and nano-particles (dielectric and conductive) and different illumination configurations (single beam, holographic geometry, and spatial light modulator projection). The report also pays attention to the physical basis of the method, namely, the coupling of the evanescent photorefractive fields to the dielectric response of the nano-particles. The role of a number of physical parameters such as the contrast and spatial periodicities of the illumination pattern or the particle deposition method is discussed. Moreover, the main properties of the obtained particle patterns in relation to potential applications are summarized, and first demonstrations reviewed. Finally, the PV method is discussed in comparison to other patterning strategies, such as those based on the pyroelectric response and the electric fields associated to domain poling of ferroelectric materials.
Optical and optoelectronic techniques for micro-and nano-object manipulation are becoming essential tools in nano-and bio-technology. A remarkable optoelectronic technique that has experimented a strong development in the last few years is the so called photovoltaic optoelectronic tweezers. It is based on the light-induced electric fields generated by the bulk photovoltaic effect in certain ferroelectrics such as LiNbO3. The technique is simple and versatile, enabling a successful manipulation of a large variety of micro-and nano-objects with only optical control, without the need of electrodes or power supplies. However, it is still a challenge for this tool, to handle objects immersed in aqueous solution due to the electric screening effects of polar liquids. This has hindered their application in biotechnology and biomedicine where most processes develop in aqueous solution. In this work, a new efficient route to overcome this problem has been proposed and demonstrated. It uses photovoltaic optoelectronic tweezers to manipulate aqueous droplets, immersed in a non-polar oil liquid, but hanging at the interface air-oil. In this singular configuration, the high electric fields generated in the photovoltaic substrate allow a simple and flexible manipulation of aqueous droplets controlled by the light. Droplet guiding, trapping, merging and splitting have been achieved and efficient operation with water and a variety of biodroplets (DNA, sperm, and PBS solutions) have been demonstrated. The reported results overcome a main limitation of these tweezers to handle bio-materials and promises a high potential for biotechnological and biochemistry applications including their implementation in optofluidic devices.
ID and 2D patterning of uncharged micro-and nanoparticles via dielectrophoretic forces on photovoltaic z-cut Fe:LiNb0 3 have been investigated for the first time. The technique has been successfully applied with dielectric micro-particles of CaC0 3 (diameter d = 1-3 urn) and metal nanoparticles of Al (d = 70 nm). At difference with previous experiments in x-and >>-cut, the obtained patterns locally reproduce the light distribution with high fidelity. A simple model is provided to analyse the trapping process. The results show the remarkably good capabilities of this geometry for high quality 2D light-induced dielectrophoretic patterning overcoming the important limitations presented by previous configurations.
This work reports a pioneer application of the bulk photovoltaic effect in the biomedical field. Massive necrotic cell death was induced in human tumour cell cultures grown on a bulk photovoltaic material (iron-doped lithium niobate, LiNbO(3):Fe) after irradiation with visible light. Lethal doses (≈100% cell death) were obtained with low-intensity visible light sources (10-100 mW cm(-2) irradiances) and short exposure times of the order of minutes. The wavelength dependence to induce the lethal effect observed is consistent with that corresponding to the bulk photovoltaic effect generation in LiNbO(3):Fe. Necrosis also occurred when cultured tumour cells were exposed to LiNbO(3):Fe microparticles and visible light.
The study and applications of ferroelectric materials in the biomedical and biotechnological fields is a novel and very promising scientific area that spans roughly one decade. However, some groups have already provided experimental proof of very interesting biological modulation when living systems are exposed to different ferroelectrics and excitation mechanisms. These materials should offer several advantages in the field of bioelectricity, such as no need of an external electric power source or circuits, scalable size of the electroactive regions, flexible and reconfigurable "virtual electrodes", or fully proved biocompatibility. In this focused review we provide the underlying physics of ferroelectric activity and a recount of the research reports already published, along with some tentative biophysical mechanisms that can explain the observed results. More specifically, we focused on the biological actions of domain ferroelectrics, and ferroelectrics excited by the bulk photovoltaic effect or the pyroelectric effect. It is our goal to provide a comprehensive account of the published material so far, and to set the stage for a vigorous expansion of the field, with envisioned applications that span from cell biology and signaling to cell and tissue regeneration, antitumoral action, or cell bioengineering to name a few.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.