White blood count (WBC) with differential counts and packed cell volume (PCV) were studied in 100 pregnant and 30 non-pregnant control women aged 18-45 years. Eighty of the pregnant women were homozygous HbAA and 20 heterozygous HbAS. The non-pregnant women's PCV, lymphocyte and eosinophils counts were significantly higher (p < 0.005) while their leucocytes neutrophil counts were significantly lower (p < 0.005) compared with HbAA and HbAS pregnant women. However, HbAS pregnant women had higher leucocyte, lymphocyte and eosinophil counts compared with HbAA, but these were not significant. There were no variations in basophil and monocyte counts. HbAA pregnant women had no change in PCV but significant changes occured in leucocyte and neurophil counts with increase in the second trimester with decreasing lymphocyte and eosinophil counts in the second and third trimesters. However, HbAS pregnant women had significant increase in PCV in their first trimester, leucocyte and neutrophil counts in their third trimester but no variation in lymphocyte, eosinophil and basophil and monocyte counts. The increased leucocyte and neutrophil counts in the second http://www.bioline.org.br/request?rh02042 (1 of 7)10/20/2004 11:50:36 AM http://www.bioline.org.br/request?rh02042 trimester in HbAA and third trimester in HbAS may be due to genetic factor and/or oestrogen secretion reaching production peak at different periods of pregnancy. The relative increase in these haematological indices in HbAS women may be a protective mechanism against infection during pregnancy. (Afr J Reprod Health 2002; 6[3]: 112-116) RÉSUMÉNumérations leucocytaires chez les femmes nigérianes enceintes qui ont des traits drépanocytaires. Nous avons étudié le nombre de globules blancs et le formulaire leucocytaire et l'hématocrite chez 100 femmes enceintes ainsi que chez 30 femmes témoins âgées de 18-45 ans, qui n'étaient pas enceintes. 80 femmes parmi les femmes enceintes étaient des homozygotes de type HbAA et 20 étaient des hétérozygotes, de type HbAs. Le formulaire leucocytaire, la numération lymphocytaire et la numération des éosinophiles étaient appréciablement élevés alors que leur numération leucocytaire des neutrophiles était appréciablement peu élevée (p 0, 005) comparée à HbAA et HbAS chez les femmes enceintes. Toutefois, les femmes enceintes de la catégorie HbAS avaient des numérations leucocytaires, lymphocytaires et des neutrophiles plus élevés par rapport à HbAA, mais ceux-ci n'étaient pas significatifs. Il n'y avait pas de variations quant aux numérations des basophiles et aux numérations monocytaires. Il n'y avait pas de modification dans le formulaire leucocytaire chez les femmes enceintes de type HbAA, mais il y a eu des modifications assez importantes au niveau des numérations leucocytaires et au niveau de taux des polynucléaires neutrophiles au fur et à mesure que le second trimestre augmentait que les numérations leucocytaires et des éosinophiles baissaient au cours de second et du troisième semestres. Néanmoins, il y a eu des h...
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