Amniotic fluid endothelin-1 (ET-1) levels were measured in 38 euploid and in 15 aneuploid pregnancies in the 17th gestational week. Varying distribution of the peptide levels was found in the two groups, with higher values in the pathological cases. Should this finding be confirmed in maternal blood, ET-1 could represent a further analyte to be used in prenatal screening for aneuploidy.
For this method, the calculation of Auto FS used the following formula: Auto FS (%) = (diastolic dimension-systolic dimension)/ diastolic dimension × 100. The values measured between the ventricular septum and at right side are defined as R-Auto FS. That at left side is L-Auto FS. And the value between both ventricular walls was defined as Combined-Auto FS. About recipients of TTTS we evaluated the tendency by Z score. The equipment was Arietta70 or 850 (Hitachi). This study was approved by the ethics committee of our facility and was performed upon obtaining the written informed consent of the subject mother. Results: The data was obtained from 578 of normal fetuses and 9 of TTTS. In normal fetus all Auto FS decreased significantly with gestational age (Spearman correlation analysis R-Auto FS: p =-0.427 L-Auto FS: p =-0.258, Combined Auto FS: p =-0.469 respectively). In recipients of TTTS, the mean of Z score were R-Auto FS:-0.88, L-Auto FS:2.46, Combined-Auto FS:-1.64. Conclusions: We consider Auto FS can evaluate fetal cardiac function clinically. In recipient twins R-Auto FS and Combined-Auto FS decreases. We considered these decreased FS might reflect the deterioration of the cardiac function of recipients of TTTS. VP18.12 Fetal pulmonary artery sling: prenatal diagnosis and outcome
We evaluated if the response to prostaglandin E2 (PGE2) induction, in pregnancies completing 41 gestational weeks, is correlated to amniotic fluid index (AFI) values. A follow-up was performed from the time of the induction to the time of delivery of 63 pregnancies resulting in a spontaneous delivery showing unfavorable cervical examination at 41 weeks of gestation. This was induced by means of intracervical administration of PGE2 gel (Dinoprostone 0.5 mg). If the cervix was still unfavorable after 12 h, another gel administration followed. The number of PGE2 administration and AFI were both used as variables to correlate the time remaining before the delivery and the probability of delivery (Kaplan-Meier and Cox algorithms). Gestational age, parity, neonatal weight, and APGAR 5′ were used as covariates. A cut-off of AFI >6 better discriminates two groups regarding the probability of delivery at paired hours from the beginning of the induction. A statistically significant difference was demonstrated in only those patients which did not deliver within 12 h (44 cases). Multivariate analysis (Cox regression) yielded an adjusted odds ratio associated to the probability of delivery of 0.47 (0.23–0.95, 95% CI, p value = 0.0354) for AFI≤6 vs. AFI >6.
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