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Synthesis of 1,2,3,4-Tetrahydroisoquinolines Containing Electron-Withdrawing Groups.-The synthesis of title isoquinolines containing electron-withdrawing groups in the aryl ring was required for the preparation of novel pharmaceutical agents. For the tetrahydroisoquinolines the heterocyclic ring was formed via double displacement with a nitrogen nucleophile and a substituted benzene derivative. This intermediate (V) was also used for the preparation of the isochroman (XI). -(QUALLICH, G. J.; MAKOWSKI, T. W.; SANDERS, A. F.; URBAN, F. J.; VAZQUEZ, E.; J. Org.