Objective:This study aimed to determine the cephalometric association of mandibular size/length to the surface area and dimensions of the frontal and maxillary sinuses.Materials and Methods:This descriptive study was conducted on 116 digital lateral cephalograms of 38 patients with skeletal Class I malocclusion (normal), 40 patients with skeletal Class II malocclusion with mandibular deficiency, and 38 patients with skeletal Class III malocclusion with mandibular excess. Both male and female patients were included. Using AutoCAD 2016 software, the anteroposterior dimension, height and surface area of the frontal and maxillary sinuses, mandibular body length and cephalometric indices including anterior and posterior cranial bases, and growth pattern indices were measured on lateral cephalograms.Results:Dimensions and surface area of the frontal and maxillary sinuses in skeletal Class III malocclusion were greater than those in other groups. These variables were significantly correlated with the mandibular body length. The coefficient for the correlation of height, width, and surface area of the frontal sinus with mandibular body length was 0.253, 0.284, and 0.490, respectively. The coefficient for the correlation of height, length, and surface area of the maxillary sinus with mandibular body length was 0.346, 0.657, and 0.661, respectively. These variables (except for the frontal sinus width) had a significant correlation with the anterior and posterior cranial bases. The frontal sinus width had a significant correlation with the anterior cranial base. These variables in males were greater than those in females.Conclusion:The dimensions and surface area of the frontal and maxillary sinuses in skeletal Class III malocclusion were greater than those in other groups. These variables (except for the frontal sinus width) had a significant correlation with the anterior and posterior cranial bases and mandibular body length.