K anser gerek çeşitli patofizyolojik mekanizmalar yoluyla gerekse daha sonrasında uygulanan kemoterapi/ radyoterapi gibi ek tedavilerin sitotoksik yan etkisiyle fertiliteyi olumsuz yönde etkiler. Primer testiküler kanserlerin lokal etkileri sonucu hem ipsilateral hem de kontralateral testiste fonksiyonu bozabilir. Gerek genitoüriner maligniteler gerekse non-genitoüriner maligniteler hipotalamo-hipofiz-gonadal aks üzerine etki ederek spermatogenezi düzenleyen endokrin fonksiyonları da bozabilir. [1] Diğer taraftan, sistemik inflamasyon ve tümöre bağlı sitotoksik otoimmün yanıt da spermatogenezi olumsuz yönde etkilemektedir. Ayrıca, kanser ve tedavisi ile ilişkili psikolojik morbidite de hastada cinsel işlev bozukluğu ile üreme po-ABSTRACT Recently, developments in the cancer treatment have led to increased quality of life as well as lifetime expectations. Especially, surgical, chemotherapeutic and/or radiotherapeutic treatment of testicular or non-genitourinary tumors such as lymphoma/leukemia which observed in men in adolescent and adulthood period can cause to decreased sperm production. Sperm freezing before the treatment is extremely important for the salvage of future fertility. However, an important part of the patients can be accompanied by azoospermia or cryptozoospermia. In this case, it is necessary to perform sperm search from the testicle by microdissection method. This procedure is called as Onco-TESE.
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