PROCEEDINGS OF THE BIOCHEMICAL SOCIETY no inhibition with respect to hydroxylamine and non-competitive inhibition with respect to glutamate. It was also found that AMP is a powerful competitive inhibitor of the kidney enzyme with respect to hydroxylamine. The K, is approx. 1OuM. AMP does not affect the activity of muscle glutamine synthetase. Although it is difficult to interpret several of these observations, they underline further the-marked difference in properties between the enzymes from the two tissues. This work was carried out while M. P. G. held a Travel Fellowship of the Fondacion Juan March.
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