CEPHALALGIAKruglak L, Nathan I, Korczyn AD, Zolotov Z. Berginer V. Dvilansky A. Platelet aggregability, disaggregability and serotonin uptake in migraine. Cephalalgia 1984;4:221-5. Oslo. ISSN 0333-1024 Several disturbances in platelet function have been reported in migraineurs including serotonin (5-HT) metabolism and abnormal aggregability of platelets. The present work compared platelets taken from migraineurs during attacks and at headache-free periods with those of controls. The results demonstrated a tendency to increased aggregability during attacks compared to headache-free periods, and lower still in controls. Kinetic analysis of 5-HT uptake revealed normal K m , increased V max values and lower imipramine inhibition in migraineurs (both during headache and at headache-free periods). However, although the differences were significant statistically, they were small, and their clinical relevance remains to be proven.
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