Thirty Mycobacterium tuberculosis strains (8: INHR/INHR, 12: INHR/RIFS, 10: INHS/RIFS) were examined against MICs of epiroprim (EPM) and isoniazid (INH) separately or in association. EPM alone proved to be insufficiently active against the various mycobacterial isolates (MIC ≧256 µg/ml). The observed average sensitivity to the association of EPM plus INH was, in contrast, considerably increased, as reflected by reduced MICs and lower percentages of resistant strains. MICs ranged between 16 and 32 µg/ml EPM and 2 and 4 µg/ml INH for INHR strains. All INHS isolates were inhibited by a concentration of 0.125 µg/ml EPM and 0.06 µg/ml INH. The fractional inhibitory concentration indices indicated an additive activity on INHR/RIFR strains and a synergistic activity on INHR/RIFS and INHS/RIFS strains. The synergistic activity of this drug association needs to be confirmed in an animal model.
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