A rapid chemiluminescence method is described for the determination of naproxen, based on the chemiluminescence reaction with cerium(IV) in sulfuric acid medium. The optimum conditions for the chemiluminescence emission were investigated. With the integrated chemiluminescence intensity for 15 s after CeIV injection as a quantitative parameter, naproxen can be determined over the concentration range 100-1000 ng ml-1 with a detection limit of 15 ng ml-1 and with RSDs (n = 10) of 0.9% and 1.5% at levels of 1000 and 100 ng ml-1, respectively. The method was applied to the determination of naproxen in pharmaceutical preparations.
A rapid method by chemiluminescence is described for the determination of naltrexone. The method is based on the chemiluminescence reaction with potassium permanganate in sulfuric acid medium. The optimum conditions for the chemiluminescence emission were investigated. With the integrated chemiluminescence intensity for 10 s after KMnO4 injection as a quantitative parameter, naltrexone can be determined over the concentration range 50-1000 ng ml-1 with a detection limit of 2.5 nm ml-1 and with a RSD (n = 10) of 0.9% and 0.5% at levels of 1000 and 100 ng ml-1, respectively. The method was applied to the determination of naltrexone in pharmaceutical preparations.
Reduction of optically active mandelamides by lithium aluminium hydride to the corresponding amines without appreciable racemisation permits deduction of the configuration of sympathomimetic amines from that of suitably substituted mandelic acids. In this way the configuration of adrenaline and of its 9-hydroxyphenyl analogue has been correlated with that of the mandelic acid, through 3-amino-kmethoxy-and 4-hydroxymandelic acid. The configuration of ~(-)-mandelic acid is found for natural laevorotatory adrenaline and its lzvorotatory p-hydroxyphenyl analogue.KNOWLEDGE of configurational relationships in the field of optically active sympathomimetic amines is an importml element in interpreting and forecasting the specific biological properties of these bases. We here report a purely chemical determination of the configuration of adrenaline and its $-hydroxyphenyl analogue.Freudenberg 1 suggested, but without experimental evidence, that (-)-adrenaline had configuration (I) by analogy with (-)-ephedrine and (-)-+ephedrine whose steric configuration had been unambiguously established (all formulz in this paper are Fischer projections). Blaschko, Holton, and Stanley2 later found that Dalgliesh and Mann's racemic 3 : 4-dihydroxyphenylserine was decarboxylated by an L-amino-acid decarboxylase from Streptococczcs faecalis to (-)-noradrenaline in 50% yield; Dalgliesh suggested that the serine used had the erythro-configuration and consequently that the configuration of adrenaline was the opposite of (I), basing this on the well-known biogenetic relation of noradrenaline to adrenaline. However, from infrared spectrophotometric studies Bolhofer ascribed to the same substrate the threo-configuration, and Hartman, Pogrund, Drell, and Clark showed that the other racemic form of 3 : 4-dihydroxyphenylserineY to which they ascribe the erythro-configuration, is enzymically decarboxylated to (+)-nor-
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.