There is a high prevalence of B. tropicalis allergy in the tropical northern KZN region and a much lower prevalence in the Johannesburg region. Routine testing for B. tropicalis allergy should be employed in northern KZN.
Primary immune deficiency disorders (PIDDs) are common and underdiagnosed. Predominant antibody deficiencies (PADs) are the most common type of immune deficiency and comprise 55% of the immune deficiencies diagnosed. [1] Although immunoglobulin A (IgA) deficiency remains the most common type of PID, common variable immunodeficiency disorders remain the most common symptomatic PID for which medical therapy is sought.
Corresponding author: R J Green (robin.green@up.ac.za)The human body is exposed to a multitude of microbes and infectious organisms throughout life. Many of these organisms colonise the skin, gastrointestinal tract (GIT) and airway. We now recognise that this colonisation includes the lower airway, previously thought to be sterile. These colonising organisms play an important role in disease prevention, including an array of chronic inflammatory conditions that are unrelated to infectious diseases. However, new evidence of immune dysregulation suggests that early colonisation, especially of the GIT and airway, by pathogenic micro-organisms, has deleterious effects that may contribute to the potential to induce chronic inflammation in young children, which may only express itself in adult life.
Lymphangiomatosis is a rare disorder and the underlying aetiology is poorly understood. The diagnosis is difficult, and relies on various clinical, radiological and histological features. Therapy is diverse, with combinations of treatment required to achieve disease control. The prognosis is guarded, and currently a vast amount of work is being undertaken to understand the disease, and to find focused therapy. We present a case of histologically, and radiologically proven lymphangiomatosis in a 4-year-old child who presented with nonspecific symptoms.S Afr Respir J 2017;23(2):35-38.
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