2. Deacetylcephalosporin C has been isolated as a crystalline sodium salt. It resembles cephalosporin C in a number of its properties, including its ultraviolet-absorption spectrum, but is more readily converted into the lactone, cephalosporin Cc, in acid solution. 3. Deacetylcephalosporin C shows about 20 % of the activity of cephalosporin C against Staphylo-coccu8 aureu?s (Oxford strain) and Salmonella typhi. It is highly resistant to hydrolysis by purified preparations of penicillinase from Bacillus cereus strains 569/H and 5/B. 4. Deacetylcephalosporin C and cephalosporin C may be distinguished by paper chromatography. We wish to thank Mrs M. Loveridge for expert technical assistance, and Miss B. Crompton for help with manometric experiments. We are grateful to the staff of the Medical Research Council's former Antibiotics Research Station, Clevedon, Somerset for supplies of cephalosporin C and to Dr M. R. Pollock for samples of purified penicillinase from Bacilus cereus strains 569/H and 5/B. J. D'A. J. is indebted to the National Research Development Corporation for financial support.

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When Evans blue is injected into the circulation of normal individuals a constant dye concentration is reached within 20 min. and this concentration is maintained for a further 40 min. Subsequently it diminishes at a rate of about 5 % per hour [Crooke & Morris, 1942]. In the course of investigations uponi the plasma volume in patients with shock, however, unaccountable alterations in the concentration of dye were sometimes found. A systematic examination of the factors which might be responsible for such anomalous dye concentration curves has therefore been made.At first the anomalous results were thought to be associated with shock, but this was disproved by a normal curve occurring in a patient with severe traumatic shock, and whose systolic blood 1 30-pressure was consistently below 60 mm.a Hg (Fig. 1 a). In contrast to this, a e moderately shocked patient with second 1 40-X and third degree burns of the hands and g l30-face, whose systolic blood pressure variedfrom 140 to 150mm. Hg, had an anomalous g 1 20-O curve (Fig. 1b).

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