Background: Hypertension is the major health problem throughout the world because of its high prevalence and its association with increased risk of cardiovascular diseases. Aim: The aim of present study was to evaluate the hematological changes in primary hypertension in Sangareddy, Andhra Pradesh. Materials and Methods:In the present study, a total of 100 patients diagnosed for primary hypertension and 100 normotensive subjects were included. All the participants after taking informed consent were subjected to detailed history and hematological analysis. Students-'t' test was used to find out the significance of differences. P values less than 0.05 was considered the level of significance. Result: It was observed that the mean values of Hemoglobin, Erythrocyte count, Hematocrit, MCH and MCHC were increased in primary hypertension while, the mean levels of MCV were found to be lower in the hypertensive group when compared to normotensive subjects. Conclusion: Hypertension has impact on hematocrit, hemoglobin, RBC count, WBC count and Platelet count which can be used for early detection of hypertensive prone individuals.