A facile
synthetic route toward either 3- or 5-fluoroalkyl-substituted
isoxazoles or pyrazoles containing an additional functionalization
site was developed and applied on a multigram scale. The elaborated
approach extends the scope of fluoroalkyl substituents for introduction
into the heterocyclic moiety, and uses convenient transformations
of the side chain for incorporation of fluoroalkyl-substituted azoles
into the structures of biologically active molecules. The utility
of the obtained building blocks for isosteric replacement of alkyl-substituted
isoxazole and pyrazole was shown by the synthesis of fluorinated Isocarboxazid
and Mepiprazole analogues.
Our interest in the synthesis and studies of isoxazolidine derivatives because of their relevance in organic synthesis 1, 2 and their role as biologically active substances has led us to consider co-ordination abilities these compounds, which have not been studied yet. The metal complexes with isoxazolidines as ligands are attracted our attention as one of the methods of purification and separation of isomeric isoxazolidines that is also important from a biological point of view. A few Pd(II),) have been prepared and characterised by 1 H, 13 C, 31 P 1-D and HMBC, ROESY, COSY 2-D NMR spectroscopy. The configurations of isoxazolidines have been assigned by analysis of NMR coupling constants and by nuclear Overhauser effect. It has been shown that isoxazolidines may act as bidentate (N,N-; O,N-) or monodentate (N-pyridine) donors. The molecular structure of trans-[PdCl 2 (L 2 )PEt 3 ] has been established by means Xray crystallography. The crystal structure of trans-[PdCl 2 (L 2 )PEt 3 ] contains square-planar coordination polyhedrons of palladium ions. The L 2 is coordinated in a monodentate manner via the pyridine nitrogen atom. The isoxazolidine fragment has an envelope conformation.[1] DeShong P. "A Nitrone-Based Cycloaddition Approach to the
Regioselective Synthesis of New Isoxazolines with Pyridyl Substituents -[via 1,3-dipolar cycloaddition of nitrones (I) to 4-vinylpyridine (II)]. -(LYSENKO, A. B.; LAMPEKA, R. D.; Russ.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.