The effect of 9 ppm halothane, a subanesthetic concentration, was studied on the reproductive ability and pregnancy outcome in white rats. Pregnant females were exposed for 4 h per day during the whole gestation period. Male animals were subjected to halothane inhalation for 4 h daily, 5 days per week for 6 or 8 months. In the exposed females higher rates were established for early interruption of pregnancy (all implants dead) and for embryonic death in the later periods of intrauterine life compared to controls. Deciduomata were found in 22.22% (P less than 0.05) of pregnant treated females. Control females mated to exposed males showed a higher incidence of preimplantation loss (36.36% (P less than 0.05) of those mated with males exposed for 6 months had deciduomata). Decreased fertility in males, expressed particularly in the 8-month treated group, was also demonstrated (13.33% inseminated females, compared to 35% in the control group).
patients in both groups were recorded and results were compared both within and between the groups. Results Significant improvements were observed in both groups in morning stiffness, joint pain, Ritchie articular index, serum CRP and ESR levels compared to values before treatment, beginning from first month to sixth month (p < 0.001). In the functional assessment; significant improvements were observed in both, determined beginning from the first month to sixth month compared to before treatment both in group receiving a night dose prednisolone and morning dose prednisolone (p < 0.05). In comparison of morning stiffness, joint pain, Ritchie articular index and its functional assessment, and serum CRP and ESR levels in both groups, no significant difference was obtained from first month to sixth month (p > 0.05). Conclusion Low dose prednisolone therapy in treatment of RA significantly suppresses the activity of disease beginning from the first month. This condition is kept until the sixth month. However, administration of the medication either given at morning hours classically or at night according to the diurnal rhythym of disease activity doesn?t affect the results of the treatment.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.