Potassium fluoride doped natural phosphate, inexpensive and environmentally friendly catalyst, is shown to be an efficient basic catalyst for the N1/N9 alkylation of different nucleobases as synthons for PNAs.
Natural Phosphate as Lewis Acid Catalyst: A Simple and Convenient Method for Acyclonucleoside Synthesis.-Natural phosphate can be used as Lewis acid catalyst for the N-alkylation of silylated pyrimidine bases with acetoxyethylacetoxymethyl ether (II) to acyclonucleosides such as (III). -(ALAHIANE, A.; ROCHDI, A.; TAOURIRTE, M.; REDWANE, N.; SEBTI, S.; LAZREK, H. B.; Tetrahedron Lett. 42 (2001) 21, 3579-3581; Lab. Chim.
Fluoride Doped Natural Phosphate as Basic Catalyst. -Inexpensive and environmentally friendly KF-doped natural phosphate is shown to be an efficient basic catalyst for the N-alkylation of various nucleobases as synthons for polyamide nucleic acids. -(ALAHIANE, A.; TAOURIRTE, M.; ROCHDI, A.; REDWANE, N.; SEBTI, S.; ENGELS, J. W.; LAZREK*, H. B.
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