A cross-sectional multicentre study based on computer-assisted telephone or face-to-face interviews with RRMM patients was undertaken. A Discrete-Choice-Experiment (DCE) with four attributes (drug administration: application 1 (tablet once/day+once/week, 2-hour physician visit once/month), application 2 (tablet once/ day+twice/week, 2-hour physician visit once/month) or application 3 (tablet once/ day+once/week, physician visit twice/week lasting 3-4 hours incl. infusion); time without disease progression: 26/20/17 months; possibility of side effects affecting the blood: 12%/19% probability; possibility of heart failure: 2%/4%) was implemented. Preferences were analysed based on conditional logit regression models. Results: Analysis was conducted for 84 patients (mean age: 62.75 years; 63.10% male; mean disease duration: 5.51 years). Drug administration was the most important attribute for patients' choices (relative importance 38.83%). Patients strongly preferred application 1 (utility: 1.79; p< 0.001), followed by application 2 (1.46; p< 0.001), both compared to application 3. The second most important attribute was disease-progression-free time (38.63%) with utilities of 1.78 for 26 months (p< 0.001) and 0.81 for 20 months (p< 0.001), both compared to 17 months. Possibility of heart failure occurrence had an importance of 13.92% (utility of 2% vs. 4%: 0.64; p< 0.001), and possibility of side effects affecting the blood had the lowest importance (8.62%; utility of 12% vs. 19%: 0.40; p< 0.001). Derived utilities for currently available RRMM treatment options were 3.21 for Ixazomib+Lenalidomide+Dexamethasone, 2.75 for Lenalidomide+Dexamethasone and 1.89 for Carfilzomib+Lenalidomide+Dexamet hasone. ConClusions: RRMM patients prefer treatment options with an all-oral application mode, a longer disease-progression-free time and a lower probability of side effects. In order to receive a more convenient therapy, patients are willing to accept slightly less efficacy.
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