Aim. To find out the problems in children health in long-time postoperative period after cardiosurgery using the comprehensive method for creating rehabilitation program.Methods. A prospective investigation of group of children was done before (n = 88) and in a year (n = 115), in 2 years (n = 90) and in 3 years (n = 58) after the surgical correction of congenital heart defects on the base of Kuzbass cardiological center. The anamnesis, clinical and hemodynamic aspects were studied as well as the postoperative period, residual problems after the correction, social status of the family and the comprehensive assessment was done in the both groups.Results. Before the correction the most part of children had low and very low levels of physical functioning, but there was a positive dynamic right after the surgery: the most part of children had high and middle levels (13% and 44% in a year), while the amount of children with low and very low data were reduced. Nevertheless, in 3 years after the surgery the amount of children with low and very low data was increased while the hemodynamic became better. Such tendency was mentioned with all aspects of the health.Conclusion. Despite of hemodynamic normalization the quality of life with all aspects still suffers. It predicts dangers in development and quality of life in general.
In case of pathology in the hip joint, the most appropriate operations are those that restore function. However, there is a group of patients who are shown arthrodesis as a forced measure. Considering that opinions on indications for hip closure in the aftermath of polio are contradictory, we decided to express our point of view on this issue.
Studying the long-term results of surgical correction of CHD in children is an urgent problem in the modern world, since there are currently no uniform criteria for assessing the long-term results of this type of intervention.Objective. To study the social and psychological characteristics of children with congenital heart disease after surgery to predict possible risks of adaptation disorders in the long term period.Material and Methods. Social and emotional functioning of 116 children with congenital heart disease after surgical treatment was assessed using the Pediatric Quality of Life Questionnaire PEDsQL4.0. Children were divided into two groups: children from families with (group 1) and without unfavorable social and economic factors (group 2).Results and Discussion. Lower indicators of health were observed in group of children with familial history of various unfavorable social and economic factors as well as in children with more complicated defects and comorbidities during threeyear follow-up.Conclusion. Integrated dynamic differentiated observation is essential during the follow-up of patients with congenital heart defects. While creating a rehabilitation program, it is necessary to take into account all components of health, including the psychosocial functioning of the child, and to implement a personalized approach to rehabilitation on this basis.
The paper is devoted to the development of QRS segmentation system based on deep learning approach. The considered segmentation problem plays an important role in the automatic analysis of heart rhythms, which makes it possible to identify life-threatening pathologies. The main goal of the research is to choose the best segmentation pipeline in terms of accuracy and time-efficiency. Process of ECG-signal analysis is described, and the problem of QRS segmentation is discussed. State-of-the-art algorithms are analyzed in literature review section and the most prominent are chosen for further research. In the course of the research, four hypotheses about appropriate deep learning model are checked: LSTM-based model, 2-input 1-dimensional CNN model, “signal-to-picture” approach based on 2-dimensional CNN, and the simplest 1-dimensional CNN model. All the architectures are tested, and their advantages and disadvantages are discussed. The proposed ECG segmentation pipeline is developed for Holter monitor software.
This study is aimed to investigate the effect of female autoserum on the HLA-DR expression in various subpopulations of lymphocytes obtained from spouses with children with sporadic congenital heart defects without chromosomal diseases. 78 married couples with children with congenital heart disease were included in the study group. The control group was formed from 35 married couples with healthy children. The immune response in a mixed culture of lymphocytes of spouses was evaluated by an increased HLA-DR expression in a mixed culture in relation to spontaneous cultures of lymphocytes. Primary staining of female and male lymphocytes by monoclonal antibodies to CD45 conjugated with various fluorescent dyes (PC-5 and PC-7) was performed to assess the immune response of female lymphocytes to male ones and vice versa. The activating effect of female autoserum on all subpopulations of female lymphocytes simultaneously occurred significantly less frequently in the study group compared to the control. The control group was characterized by the domination of the positive effect of female autoserum on HLA-DR expression for all subpopulations of female lymphocyte. For all female lymphocytes having HLA-DR molecule on its membrane, the blocking effect of female autoserum in the study group was significantly more expressed in relation to the control group. Thus, the effect of female autoserum is manifested in relation to the HLA-DR expression on its own lymphocytes, but not on the lymphocytes of the spouse.
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