Arabinogalactan extracted from Siberian larch on an industrial scale was found to exist as noncovalent glycoconjugates with a group of wood extractive substances (their content in arabinogalactan is ~3%). The flavonoids dihydroquercetin (prevailing in extractive substances with a percentage of ~24%), aromadendrin, and quercetin were identified among the extractive substances. Flavonoid-arabinogalactan conjugates are readily soluble in water (unlike virtually insoluble free flavonoids) and exhibit highly effective antiradical properties directly in an aque ous solution (the hydrophilic ABTS +• model). Flavonoid-arabinogalactan conjugates, as well as arabinogalactan specially purified from flavonoids, can be used as an energy and carbon source for indigenous probiotic microbes: the polysaccharide is hydrolyzed by the enzymatic system of bifidobacterial glycosidases to form reducing sugars digested into organic acids. The growth and functional characteristics of bifidobacteria are influenced by the degree of purity of the polysaccharide. Thus, flavonoid-arabinogalactan conjugates retard the growth of bifidobacteria and the formation of organic acids, which can be attributed to the antimicrobial activity of flavonoids (antiradical disruption of physiological redox signaling of microbial cells).
The therapeutic efficacy of a composition of amphotericin B and dialdehyde dextran was much higher than that of amphotericin B in the therapy for systemic candidiasis. This conclusion was derived from the earlier and progressive decrease in the number and size of candidal granulomas in the kidneys. The composition of amphotericin B and dialdehyde dextran was more potent than amphotericin B in decreasing the nephrotoxic effect of C. albicans. The opposite strains of CBA and C57Bl/6 mice differed in morphological signs of granulomatosis in the kidneys, but not in the nephrotoxic effect of C. albicans metabolites.
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