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The paper reports on finding the effect of a strong change in the microwave losses in an HTSbased coplanar waveguide (CPW) at certain values of the input power P in and direct current I dc .CPW on the basis of 150 nm thick YBa 2 Cu 3 O 7-δ epitaxial film on a single crystal MgO substrate was studied experimentally. A sharp and reversible transition of the CPW into a strongly dissipative state at the certain meanings of P in and I dc depending on temperature was observed.Apparently the effect can be explained by self-heating of HTS structure caused by magnetic flux flow under the joint influence of MW and DC.Since discovery of high-temperature superconductors (HTS) in 1986 [1] a lot of attention has been given to studying nonlinear properties of HTS in microwave (MW) fields [2][3][4].

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