The present hydrochemical study at the Lower Volta River (Akuse to Sogakope area), Ghana was conducted by determining the physico-chemical parameters (pH, temperature, total dissolved solute, electrical conductivity, total hardness, phosphate (PO 4 3-), nitrate (NO 3 -), sulfate (SO 4 2-), dissolve oxygen (DO), biological oxygen demand, calcium (Ca 2? ), sodium (Na ? ), magnesium (Mg 2? ), total iron (Fe), manganese (Mn), copper (Cu) nickel (Ni), and total chromium (Cr) at 38 sampling sites during the wet and the dry seasons. The physical and ionic parameters were mostly found within the WHO (Guidelines for drinking-water quality, 3rd edn, Geneva 2004) standard for drinking water. The trace metals except Cu at some sites recorded values above the WHO (Guidelines for drinking-water quality, 3rd edn, Geneva 2004) standard for drinking water. This shows that the river water is not entirely fit for drinking. Mean values of physico-chemical parameters were mostly found to be high in the dry season as compared to the wet season. Cluster analysis (CA) and principal component analysis (PCA) were employed to evaluate the water quality and the interrelationship between variables. CA grouped the physico-chemical parameters into three groups (physical/minor ions, major ions and trace elements). Correlation analysis showed that physicochemical parameters do not vary much in terms of the sampling sites. Thus, based on obtained information, it is possible to design a future, desirable sampling strategy, which could reduce the number of sampling stations and associated costs for effective river water quality management. Results showed that four principal components (industrial effect, domestic factor, natural source and agricultural effect) accounted for 65.59 % of the total variance among the water quality parameters. PCA also identified sampling sites 69R, 63R, 51M, 87L, 35L, 74L and 84L as polluted with metals. Therefore, water quality monitoring and control of release of industrial and anthropogenic wastes into the river are strongly needed.