The article reveals the reasons for the introduction of economic sanctions and restrictions against Russia. The commodity structure of exports and imports of the Russian Federation was analyzed; the grouping of Russian regions by the volume of exports and imports with countries of the far and near abroad was carried out, which allowed identifying at least 20 regions of the Russian Federation in each group that are actively engaged in foreign economic activity. It is concluded that the industrial specialization of the regions of the Russian Federation determines the nature of their foreign economic activity: the leading regions in export are the regions in which the raw materials industries of the economy are concentrated, and in import — the regions in which the manufacturing industries, primarily mechanical engineering, are concentrated. It is proved that only nine subjects of the Russian Federation (Moscow and St. Petersburg, the Republic of Tatarstan, Krasnodar and Krasnoyarsk Territories, Sverdlovsk, Rostov, Nizhny Novgorod and Moscow regions) are key regions in the implementation of comprehensive foreign trade operations. At the same time, there are regions that work mainly for import — Kaliningrad and Kaluga regions, Primorsky Krai, and others — mainly for export — Sakhalin and Irkutsk regions. The conclusion is made about the need to develop high–tech industries, IT–sphere (hardware and software), mechanical engineering, production of own feed, seeds, plant protection products in the Russian regions.
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