The objective of the work was to study modern clinical and anamnestic features of chronic lichenoid dermatoses. Materials and methods.Clinical and anamnestic examination of 100 patients with psoriasis and 80 patients with lichen planus (LP) was carried out. In both study groups, the majority were patients 51–60 years old, the minority – patients 31–40 years old. Among patients with psoriasis, men prevailed in all age groups, among patients with LP, men prevailed in the group of 20–30 years. Results. In the general gender structure, men prevailed in the group of patients with psoriasis, women prevailed in the group of patients with LP. Comparison of the anamnestic data regarding dermatoses revealed a chronic recurrent nature, characteristic of both psoriasis and lichen planus. According to the to the duration of the disease, among patients with psoriasis, the majority were patients with a long course of more than 10 years, among patients with LP – patients with a history of less than 1 year. In the group of patients with psoriasis, the majority were patients with early onset of dermatosis, in the group of patients with LP – with a late onset after 25 years. Annual manifestations of dermatosis were recorded in the vast majority of patients with psoriasis; in patients with LP, annual manifestations of dermatosis were recorded 12 times less frequently. A family history of psoriasis was found 10 times more often than in the LP group. In patients with psoriasis, compared with patients with LP, a greater relative number of long-term forms of dermatosis (38% of cases versus 22.5%), and early forms of dermatosis, which occurred before the age of 25 (52% of cases, versus 26.5%) were found. The leading provoking factor among patients with psoriasis was recognized as psychoemotional stress (61%), and among patients with LP, infections suffered the days before (49%). Also, in patients with psoriasis, obesity and overweight were recorded 5 times more often, cardiovascular diseases – 3.6 times more often, endocrine disorders – 2.4 times more often, concomitant pathology of the digestive system – 1.5 times more often than in patients with LP. At the same time, comorbital chronic infectious states were recorded more often in LP patients than in patients with psoriasis (31.25% of cases versus 22% of cases). Conclusions. The revealed results of the clinical and anamnestic characteristics of the studied groups turned out to be homogeneous in terms of age characteristics, heterogeneous in gender characteristics, trigger factors, comorbid pathologies, and multidirectional in terms of duration, manifestations and onset of dermatosis, which requires further study and systematization of key parameters.
The aim is to study the indicators of neuroendocrine regulation in patients with chronic lichenoid dermatoses. Materials and methods. Studies of neuroendocrine system indicators were performed in two groups of patients: 1–60 patients with psoriasis, 2–56 patients with lichen planus, the control group consisted of 15 healthy individuals, whose indicators were considered normal. Determination of serotonin, histamine, histaminase, corticotropin, adrenaline in the serum of patients was performed by enzyme-linked immunosorbent assay. Results. There was a reliable increase in mean serum serotonin levels relative to control in both patients with psoriasis (228%) and patients with lichen planus (182%), histamine (85% and 76%, respectively); reliable decrease in serum histaminase level by 35% in patients with psoriasis and by 33% in patients with lichen planus relative to control and significant increase in histamine / histaminase index by 167% and 142%, respectively; reliable increase in serum corticotropin levels relative to control by 179% in patients with psoriasis and by 31% in patients with lichen planus. The level of adrenaline also significantly exceeded the control values by 43% in patients with psoriasis and by 37% in patients with lichen planus. Analysis of the average value of the adrenaline / serotonin ratio showed a decrease in its relative control by 57% in patients with psoriasis and by 52% in patients with lichen planus. Conclusions. Unidirectional changes in biochemical, enzymatic and hormonal constants of ergo- and trophotropic systems in both psoriasis and lichen planus have been reported, with the predominance of histamine biosynthesis over its inactivation and the prevalence of serotonergic system over adrenergic one, which was accompanied by significant increase in serum level of serotonin, histamin, corticotropin and adrenalin relative to control and a decrease in histaminase and the average adrenaline / serotonin ratio.
The aim of the study was search and analysis of the data of review, experimental and clinical scientific and medical publications on the issues of the possible role of VD in pathogenesis of lichenoid dermatoses. Materials and methods: An analysis of the studying of the scientific and medical literature was shown. Searching was carried out through the PubMed/MEDLINE portal from the databases of the National Center Biotechnology Information, Web of Science Core Collection, U. S. National Library of Medicine, National Institute for Health and Clinical Excellence, as well as the portals «Scientific Electronic Library eLIBRARY.RU», «Russian Science Citation Index (RSCI)» and «Index Copernicus». Conclusions: The results of studies had convincingly demonstrated that deficiency of VD in the blood, decrease vitamin D receptors activity can lead to development of lichenoid dermatoses.
Actuality. The latest and COV COVID-19.unfortunately, there is no single effective treatment for this disease, so the development of vaccines is relevant. Today, the most important component in the fight against COVID-19 infection is vaccination of the population. Of course, like any medication, the vaccine also has side effects. Side effects can be either local or general. Since usually the local manifestation is associated with the skin, the topic of our work is the dermatological side effects of the vaccine.Aim. Identify the relationship between the effect of the vaccine and dermatological side effects.Materials and methods. In the course of our work, we have processed and analyzed foreign and domestic literary sources related to this topic.Results. First of all, it is important to note that serious skin adverse reactions are very rare, and the developed vaccines have a satisfactory safety profile. Most skin reactions go away on their own and require little or no therapeutic intervention.The immunogenic effect of vaccines leads to changes in the levels of chemokines and cytokines that activate various components of the innate and acquired immune system (i.e., different subgroups of T and B cells, histiocytes/macrophages, dendritic cells, eosinophils, etc.). The skin and mucous membrane as borders with the environment are largely affected by the overall activation of the immune system
Introduction: The studying of the comorbidity of skin diseases is a priority scientific direction in modern dermatology. Comorbid conditions aggravate the course of the underlying disease, reduce the effectiveness of diagnosis and treatment can lead to chronization of the process, disability of patients. Understanding of the commonality of pathogenesis and the mutually complicating nature of comorbidity makes a possible to prescribe individual rational treatment. The aim of the study was search and analysis of the data of review, experimental and clinical scientific and medical publications on the issues of the comorbidity of LP. Materials and methods: an analysis of the studying of the scientific and medical literature was shown. Searching was carried out through the PubMed/MEDLINE portal from the databases of the National Center Biotechnology Information, U. S. National Library of Medicine, National Institute for Health and Clinical Excellence, as well as the portals «Scientific Electronic Library eLIBRARY.RU», «Russian Science Citation Index (RSCI)» and «Index Copernicus». Conclusions: The main global trends of comorbidity of LP are determined. The results of these studies can form the basis for updating of clinical guidelines for the management of patients with LP at the international and local levels.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.