The metabolic syndrome, which covers a wide variety of pathological concerns, is rapidly becoming a global pandemic. This syndrome is difficult to treat pharmacologically. Physiotherapy techniques, which have both local and systemic effects, can be employed as a suitable substitute. The purpose of this study was to investigate the therapeutic effects of a program of simultaneous physiotherapy that included migrant transcranial magnetic stimulation (TMS) and the exposure to an alternating low-frequency electrostatic field (LFEF) in the treatment of metabolic syndrome patients. Ninety patients were randomly assigned to three study groups. While continuing the usual drug therapy the first group (30 patients) received LFEF intervention, the second group (30 patients) received TMS, and the third group (30 patients) underwent the simultaneous use of these non-invasive techniques (LFEF + TMS). All treatments involved 10 sessions with daily frequency. In all the patients before and after treatment body weight, blood pressure parameters, levels of insulin, cortisol, glucose, total cholesterol, high density lipoproteins, malondialdehyde, and Schiff bases, the activity of the antioxidant enzymes catalase and of the superoxide dismutase were studied. The changes in the outcomes assessed revealed a different reaction to therapy with LFEF or TMS, as well as a greater benefit when both treatments were used at the same time. A simultaneous LFEF and TMS intervention seems a promising resource for the treatment of the metabolic syndrome, particularly of the lipid and carbohydrate metabolism disorders. However, further studies are needed to confirm these findings and investigate the underlying mechanisms.
The article analyzes the mechanisms of the effect of low-frequency electrostatic field (LESF) and transcranial magnetic stimulation (TMS), as well as their combined use, on various functional systems in patients with metabolic syndrome under placebo control. It was found that LESF activates the microcirculatory-tissue system, while TMS optimizes the hormonal regulation of carbohydrate and lipid metabolism, with both physical factors having approximately equal antithrombolytic and hypotensive effects. When used together, the biological potential of these factors is summed up. The revealed patterns were confirmed in patients with post-COVID syndrome. In addition, they showed a decrease in the activity of inflammatory processes, an improvement in blood oxygen saturation and a decrease in the severity of depression. It is concluded that it is advisable to use these technologies to correct metabolic disorders and increase the effectiveness of the treatment of post-COVID syndrome.
The paper analyzes the dynamics of indicators characterizing the state of various functional body systems in patients with metabolic syndrome with the combined use of transcranial magnetic therapy and low-frequency electrostatic field in order to identify the main predictors of effectiveness. It was found that with such exposure, against the background of a significant increase in clinical efficacy, the degree of variation of dynamic changes increases, which is due to the difference in the initial condition of patients. It was revealed that the most pronounced therapeutic effect is observed in patients with preserved reserve and adaptive capabilities in the system of hemostasis, lipid peroxidation, micro-circulatory system and insulin regulation of glucose metabolism.
This study is devoted to assessing the effect of a single simultaneous exposure to a low-frequency electrostatic field and transcranial magnetic therapy on non-specific systemic adaptation mechanisms. Objective: to evaluate the effect of a single combined exposure to a low-frequency electrostatic field and transcranial magnetic therapy on the stress-realizing and stress-limiting systems of the human body. Material and methods of research. The study involved 83 male volunteers aged 25 to 38 years (the average age was 31,4±0,33 years), who did not have any chronic diseases and risk factors for their development (the first health group), who were divided into four groups by simple fixed randomization. The first group (control group, 21 people) received placebo treatment (imitation of physiotherapy treatment with the device turned off). In the second group (main group 1, 20 people), the volunteers were singly exposed to transcranial magnetic therapy with traveling magnetic field (TMT TMF) using the device «Amo-Atos» with the attachment «Headband» (RU from 18.11.2011 №FSR 2011/12325). In the third group (main group 2, 21 people), the volunteers were singly exposed to low-frequency electrostatic field (LFESF) using the multifunctional therapeutic system «Khivamat-200» (RU from 12.04.2017 №RZN 2017/5597). To assess the stress-realizing and stress-limiting systems of the body, an analysis of heart rate variability (HRV) was performed, which allows determining the tone of the sympathetic and parasympathetic parts of the autonomic nervous system (ANS). Blood levels of ACTH, cortisol, glucagon, LPO products (malondialdehyde (MDA) and Schiff base (SB)), as well as insulin and the activity of antioxidant enzymes (SOD and catalase) were measured. The study was carried out three times: in the initial state, after 30 minutes, and a day after the end of the single exposure to the complex of physiofactors. The results obtained allow concluding that the criteria for the optimality of a combined single exposure to physiotherapeutic factors is a stable activation of stress-limiting mechanisms against the background of an initial moderate increase and gradual diminishment of stress-realizing manifestations. The dynamics of the estimated indicators observed a day after the exposure indicates the increasing adaptive capabilities of the body to minimize stress-damaging effects. A single simultaneous application of physiotherapy factors demonstrated the possibility of targeted implementation of the strategy of adaptation and control of the severity of physiological, hormonal and metabolic changes within the framework of a non-specific stress response, which opens up new opportunities for optimizing the treatment process.
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