Vitiligo is a multifactorial disorder related to both genetic and non-genetic factors. The pathogenesis of vitiligo is associated with the melanocytes destruction that may result from immune and inflammatory mediators. The autoimmune theory is the most important theory about the pathogenesis of vitiligo. The aims of the study are the evaluation and assessment of serum levels of IL17 in vitiligo patients to reveal their possible role in pathogenesis of vitiligo and to correlate their levels with the severity of the disease. Patients and Methods: In this study, thirty patients (15 male and 15 females) were included in the present study and 30 apparently healthy, age and sex matched individuals were included as a control group. Patients were recruited from the outpatient clinic of Benha University Hospitals from Dermatology, Venereology and Andrology Department. All patients were subjected to full history, full dermatological and general examination. Measurement of serum levels of IL-17 using the commercially available ELISA kit. Results: The present study revealed significant increase in serum levels of IL-17 in patients than controls. Conclusion: Vitiligo is associated with increased serum level in IL-17 indicating that IL-17 may play a significant role in the pathogenesis of vitiligo.
The exact etiopathogenesis of vitiligo is still a matter of debade. The development of white macules is the clinical hallmark of vitiligo due to the selective loss of melanocytes. The prevalence of the disease is around 0.5-1.0% worldwide. 1 Vitiligo may be a psychologically distressing condition, especially in people with darker skin because it is more evident on them. It seems to be genetically transmitted in a polygenic/multifactorial way. It has been suggested that immunological factors, oxidative stress, and/or sympathetic neurogenic disruption are the etiology; however, this is still up for debate. 2
The main purpose of the research is to study role of PRP intra-articular injection in treatment of knee osteoarthritis, and PRP effect on knee osteoarthritis symptoms specially pain, also different methods of preparations
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