黄酮类化合物调控断奶仔猪肠黏膜屏障功能的研究进展

Abstract

Flavonoids are dietary non-nutrient bioactives that are widely found in various plants and possess antioxidant, antibacterial and anti-inflammatory properties. The intestinal mucosal damage caused by weaning stress is a critical factor restricting the growth performance of piglets. As one of the pollution-free, residue-free, low-resistance alternative to antibiotics, flavonoids have extensive application value in improving the growth performance of piglets and protecting A c c e p t e d https://engine.scichina.com/doi/10.1360/SSV-2023-0264 intestinal mucosal barrier. Combined with the relevant studies of our group on the renewal of intestinal epithelial cells in weaned piglets, we attempt to sum up recent studies that the pharmacological effects and molecular mechanism of flavonoids in protecting intestinal epithelial cells, repairing damaged intestinal mucosal barriers, and regulating intestinal microbiota homeostasis in improving intestinal health of early weaned piglets. This review could provide valuable theoretical basis and practical evidence for the development and application of various natural plant-derived flavonoids as feed additives to improve intestinal function in weaned piglets.