预期错误在复合恐惧记忆提取消退中的作用

Chen, Wei; Li, Junjiao; Caoyang, Jingwen; Yang, Yong; Hu, Yanjian; Zheng, Xifu

doi:10.3724/sp.j.1041.2018.00739

Cited by 7 publications

(3 citation statements)

References 33 publications

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“…Thus, consensus has not been attained yet on whether or not the behavioral intervention of fear memory destabilization still needs prediction error. However, our results indicate that PE is critical and necessary to trigger destabilization in retrieval-extinction, congruent with previous studies (Chen et al, 2018;Das et al, 2018;Sinclair and Barense, 2018;Junjiao et al, 2019). The aim of reconsolidation constitutes to update previously consolidated memories with new data to enhance environmental adaptation (Lee, 2009).…”

Section: Discussionsupporting

confidence: 91%

“…Accumulating evidence from several studies (Diaz-Mataix et al, 2013;Sevenster et al, 2014;Alfei et al, 2015) suggests that the degree of PE during retrieval demarcates the shift from solo retrieval to reconsolidation, limbo, or extinction. Our current and previous studies also support this (Chen et al, 2018;Junjiao et al, 2019). These characteristics are referred to as reactivation-related factors, which constitute a type of boundary condition.…”

Section: Discussionsupporting

confidence: 84%

“…Finally, the primary limitation is that the control group used in our experimental design is the no PE retrieval extinction, not the standard (no retrieval) extinction. According to previous studies, retrieval without PE before intervention (behavioral or pharmacological) did not impede the return of fear, which is similar to the no retrieval intervention (Sevenster et al, 2013(Sevenster et al, , 2014Chen et al, 2018;Junjiao et al, 2019). In the present study, our hypothesis is based on previous evidence, that is, retrieval with PE can destabilize original memory, while retrieval without PE cannot (equivalent to no retrieval).…”

Section: Discussionsupporting

confidence: 76%

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Destabilizing Different Strengths of Fear Memories Requires Different Degrees of Prediction Error During Retrieval

Chen

et al. 2021

Front. Behav. Neurosci.

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Reactivation of consolidated memories can induce a labile period, in which these reactivated memories might be susceptible to change and need reconsolidation. Prediction error (PE) has been recognized as a necessary boundary condition for memory destabilization. Moreover, memory strength is also widely accepted as an essential boundary condition to destabilize fear memory. This study investigated whether different strengths of conditioned fear memories require different degrees of PE during memory reactivation in order for the memories to become destabilized. Here, we assessed the fear-potentiated startle and skin conductance response, using the post-retrieval extinction procedure. A violation of expectancy (PE) was induced during retrieval to reactivate enhanced (unpredictable-shock) or ordinary (predictable-shock) fear memories that were established the day before. Results showed that a PE retrieval before extinction can prevent the return of predictable-shock fear memory but cannot prevent the return of unpredictable-shock fear memory, indicating that a single PE is insufficient to destabilize enhanced fear memory. Therefore, we further investigated whether increasing the degree of PE could destabilize enhanced fear memory using different retrieval strategies (multiple PE retrieval and unreinforced CS retrieval). We found that spontaneous recovery of enhanced fear memory was prevented in both retrieval strategies, but reinstatement was only prevented in the multiple PE retrieval group, suggesting that a larger amount of PE is needed to destabilize enhanced fear memory. The findings suggest that behavioral updating during destabilization requires PE, and the degree of PE needed to induce memory destabilization during memory retrieval depends on the strength of fear memory. The study indicates that memory reconsolidation inference can be used to destabilize stronger memories, and the findings shed lights on the treatment of posttraumatic stress disorders and anxiety disorders.

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