神経ペプチド受容体vipr2のオリゴマー化とその機能的意義

Asano, Shigetaka; Ozasa, Kairi; Nakazawa, Takanobu; A, James Waschek; Ago, Yukio

doi:10.1254/jpssuppl.95.0_3-o-125

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“…Studies have shown that VIPR2 overexpression promotes cell proliferation in breast cancer cell lines and exacerbates tumor growth in vivo (77). Furthermore, VIPR2 has been shown to form homodimers and oligomers, which are involved in VIP-induced cancer cell migration (81). The expression of GNG11 mRNA is down-regulated in ovarian cancer patients, and its high expression is associated with poor prognosis (82).…”

Section: Discussionmentioning

confidence: 99%

Identification of Key Regulators in Pancreatic Ductal Adenocarcinoma using Network theoretical Approach

Bhattacharjee,

Ghosh

2024

Preprint

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Pancreatic Ductal Adenocarcinoma (PDAC) is a devastating disease with poor clinical outcomes which is mainly because of delayed disease detection resistance to chemotherapy and lack of specific targeted therapies. The disease's development involves complex interactions among immunological, genetic, and environmental factors, yet its molecular mechanism remains elusive. A major challenge in understanding PDAC etiology lies in unraveling the genetic profiling that governs the PDAC network. To address this, we examined the gene expression profile of PDAC and compared it with that of healthy controls, identifying differentially expressed genes (DEGs). These DEGs formed the basis for constructing the PDAC protein interaction network, and their network topological properties were calculated. It was found that the PDAC network self-organizes into a scale-free fractal state with weakly hierarchical organization. Newman and Girvan algorithm (leading eigenvector (LEV) method) of community detection enumerated four communities leading to at least one motif. Our analysis revealed 33 key regulators were predominantly enriched in neuroactive ligand-receptor interaction, Cell adhesion molecules, Leukocyte transendothelial migration pathways; positive regulation of cell proliferation, positive regulation of protein kinase B signaling biological functions; G-protein beta-subunit binding, receptor binding molecular functions etc. Transcription Factor and mi-RNA of the key regulators were obtained. Recognizing the therapeutic potential and biomarker significance of PDAC Key regulators, we also identified approved drugs for specific genes. However, it is imperative to subject Key regulators to experimental validation to establish their efficacy in the context of PDAC.

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Section: Discussionmentioning

confidence: 99%