界面活性剤によって誘発されるかゆみとケラチノサイト-ヒスタミン系の関与

Abstract

The primary function of surfactants is to remove dirt, exfoliated corneum cells, and microorganisms from the skin. However, the use of toiletries such as soaps and shampoos containing surfactants may cause adverse eŠects such as cutaneous irritation, dryness, and itching. Recently, skin pathologies, including dry skin, rough skin, and sensitive skin, have increased because of changes in living conditions and lifestyle. Although many people with skin pathologies complain of itching during and/or after skin washing using detergents, the mechanisms of detergent-induced itch are yet to be elucidated. Therefore, in this study, we investigated the mechanisms underlying surfactant-induced itching. We found that topical application of an anionic surfactant sodium laurate at an alkaline pH, but not N-lauroylsarcosine sodium salt at neutral pH, to mouse skin induced scratching, an itch-related response. Additionally, we found that the sodium laurate-induced scratching was inhibited by H 1 histamine receptor antagonist, but not mast cell deˆciency. Sodium laurate application increased histamine content and the level of the active form (53 kDa) of L-histidine decarboxylase (HDC) in the mouse epidermis, but not the dermis. Furthermore, addition of sodium laurate to a human epidermal cell culture increased histamine release and HDC levels, without aŠecting cell viability. These results suggest that surfactants with alkaline properties are pruritogenic and that the pruritus is induced by the histamine released from epidermal keratinocytes. The increase in histamine release may be attributable to the activation of HDC in epidermal keratinocytes.

Comparison of the Efficacy of Atopalm® Multi-Lamellar Emulsion Cream and Physiogel® Intensive Cream in Improving Epidermal Permeability Barrier in Sensitive Skin

“…First, disruption of permeability barrier induces cutaneous inflammation via stimulation of proinflammatory cytokine release [ 16 – 20 ], inflammatory cell maturation and infiltration [ 9 , 21 – 23 ] while inflammation is a pathophysiological feature of sensitive skin [ 24 ]. Second, barrier disruption increases the density of mast cell, a major source of histamine, in the dermis [ 7 ] whereas release of histamine can cause itching upon external stimuli [ 25 ]. The increased histamine could further disrupt epidermal permeability barrier via inhibition of keratinocyte differentiation and lipid production [ 26 , 27 ].…”

Inhibitory Effects and Potential Mechanism of Yokukansankachimpihange on SDS-induced Itch-associated Responses in Mice

“…It may cause skin irritation in both humans and animals [13,14]. Previous studies reported that adverse effects, such as skin dryness, barrier destruction, dermatitis, and itch-scratching, developed in mice following the repeated topical application of 10% SDS [15,16]. Therefore, the present study was performed to investigate the effects of YKSCH on scratching behavior induced in mice by the repeated topical application of 10% SDS.…”

“…After acclimatization for seven days, experimental procedures were initiated. The SDS model was developed according to the method reported by Inami et al [16]. All mice were intraperitoneally anesthetized with a combined anesthetic (medetomidine, 0.3 mg/kg; midazolam, 4.0 mg/kg; butorphanol 5.0 mg/kg).…”