泰国余甘子水提物中总酚含量及抗氧化活性

Iamsaard, Sitthichai; Arun, Supatcharee; Burawat, Jaturon; Sukhorum, Wannisa; Nualkaew, Somsak; Sripanidkulchai, Bungorn

doi:10.1631/jzus.b1300284

Cited by 22 publications

(22 citation statements)

References 11 publications

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“…Unfortunately, this study did not show those results; however, such biochemical analyses must be further investigated to elucidate the real mechanism underlying of PE protective effects. It can be clearly explained that PE extract used in this study is rich in phenolic contents and antioxidant capacities (Iamsaard et al, 2014b), which is similar to those of the fruit parts (She et al, 2013;Chalise et al;Sawant et al, 2010). Indeed, PE extract did not affect any male reproductive organs including sperm parameters as compared to the control.…”

Section: Discussionsupporting

confidence: 71%

“…The branch extract of Phyllanthus emblica L. (PE), authenticated for its actual species by Prof. Dr. Pranom Chantaranothai and sample kept in the KKU Herbarium (# Supatcharee Arun 01 [KKU]) , was prepared in Dr. Sitthichai Iamsaard's laboratory and proven to have high phenolic contents and antioxidant capacities (Iamsaard et al, 2014b).…”

Section: Methodsmentioning

confidence: 99%

“…Phyllanthus emblica L. (PE) or Thai-Makham Pom is a famous plant recently used as traditional medicine for many properties. All part extracts of PE have been reported to have high phenolic contents and antioxidant capacities (Iamsaard et al, 2014a(Iamsaard et al, , 2014bLiu et al, 2008;el-Mekkawy et al, 1995;Khanna & Bansal, 1975;Srivastava & Ranjan, 1967;Theresa et al, 1965;Basa & Srinivasuku, 1987). PE extract has been reported to have capacity in lipid peroxidation inhibition and anti-cancers (Krishnami & Mirunalini, 20012;Lou et al, 2011;Zhong et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Phyllanthus emblica L. Branch Extract Ameliorates Testicular Damage in Valproic Acid-Induced Rats

et al. 2015

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SUMMARY:Valproic acid (VPA), widely used in treating epileptic patients, can damage reproductive parameters causing male infertility. This study aimed to investigate protective effect of Phyllanthus emblica L. branch (PE) extract on rat testicular damage induced with VPA. Male rats were divided into 6 groups (control, VPA, 250 mg/kgBW PE only, and 50, 100, 250 mg/kgBW PE+VPA, respectively). Animals were pretreated with PE for 23 days and co-administered with VPA for 10 days before all reproductive parameters were determined. The results showed all doses of PE significantly protected the decrease testicular weight and testosterone level in VPA rats. PE significantly improved the decrease sperm concentration in VPA treated rats. Moreover, testicular histology of PE+VPA groups showed declining of testicular histopathologies as compared to VPA group. Therefore, it seems that PE branch extract can prevent testicular damages including male reproductive parameters in rats induced with VPA.

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Section: Discussionsupporting

confidence: 71%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Phyllanthus emblica L. Branch Extract Ameliorates Testicular Damage in Valproic Acid-Induced Rats

et al. 2015

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“…The amount of TPC in all LL-spl different extracts was measured using the Folin-Ciocalteu reagent method as previously described (Iamsaard et al, 2014;Singleton et al, 1999). Briefly, each aqueous LL-spl extract (0.2 mL, 0.2 mg/mL) was added into a test tube containing 1 mL of the Folin-Ciocalteu reagent (10 %, v/v) and incubated for 5 min before adding 3 mL of 0.2 g/mL sodium carbonate.…”

Section: Determination Of Tpcmentioning

confidence: 99%

“…The radical scavenging activity of LL-spl extracts was determined by using a DPPH assay as previously described (Iamsaard et al, 2014;Brand-Williams et al, 1995). Briefly, the distilled water-diluted solution of each LL-spl extract (10, 20, or 40 min) was prepared from a concentrated extract stock into five concentrations (7,12,19,25,32,38, and 44 µg/mL, respectively) to complete a concentration plot.…”

Section: Determination Of Tpcmentioning

confidence: 99%

Antioxidant Capacity and Acute Testicular Toxicity of Leucaena leucocephala Aqueous Shoot Tips Plus Young Leaves Extracts

et al. 2016

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BURAWAT, J.; UABANDIT, N.; SRIPANIDKULCHAI, B.; NUALKAEW, S. & IAMSAARD, S. Antioxidant capacity and acute testicular toxicity of Leucaena leucocephala aqueous shoot tips plus young leaves extracts. Int. J. Morphol., 34(2):514-521, 2016. SUMMARY:This study aimed to determine the antioxidant capacity of the Leucaena leucocephala aqueous shoot tips plus young leaves (LL-spl) extracts among three different fractions (LL-spl 10, 20, and 40 min) and to examine its acute toxicity on male reproductive parameters. The amount of the total phenolics in LL-spl extract was determined using a Folin-Ciocalteu reagent method and its antioxidant capacity was analyzed using 1, 1-diphenyl l-2-picrylhydrazyl radical scavenging and ferric reducing antioxidant powder methods. The LL-spl extract fraction with highest antioxidant capacity was used in animal treating. Male rats were divided into three groups (n= 5); control and groups treated with LL-spl 400 and 600 mg/Kg body weight for consecutive 40 days. The results showed that the LL-spl 40 min fraction possessed the highest antioxidant capacity. In addition, the LL-spl 400 and 600 groups showed no differences in weights of body, testis and epididymis, serum testosterone levels, and expression of testicular steroidogenic acute regulatory (StAR) protein. Significantly, LL-spl extract reduced the weight of seminal vesicle, sperm concentration, and seminiferous diameters compared with control. Moreover, LL-spl extract had adverse effect on testicular histology in inducing of seminiferous atrophy and degeneration including dilated blood vessels in interstitial tissue. It was concluded that although LL-spl extract possessing antioxidant capacity, in short term consumptions, it could be toxic to some male reproductive organs especially damaging testicular tissues.

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Protective effects of Phyllanthus emblica against myocardial ischemia-reperfusion injury: the role of PI3-kinase/glycogen synthase kinase 3β/β-catenin pathway

et al. 2015

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Clinical studies of Phyllanthus emblica (P. emblica) have shown that it increases production of nitric oxide, glutathione, and high-density lipoprotein (HDL); decreases low-density lipoprotein (LDL), total cholesterol, triglycerides, and high-sensitivity C-reactive protein (hsCRP); and significantly inhibits platelet aggregation. The following study was designed to examine the effect of P. emblica treatment on myocardial ischemia-reperfusion (I/R) injury and identify the molecular targets and its underlying mechanism(s). Experimental animals were divided into four groups: control sham (CS), P. emblica sham (PS), control I/R (CIR), and P. emblica I/R (PIR). Rats in the P. emblica groups were gavaged with aqueous P. emblica solution (100 mg/kg body weight) for 30 days. After 30 days of gavaging, the I/R group underwent I/R surgery (45-min ischemia) followed by 4 or 30 days of reperfusion. Rats in the sham group underwent surgery without ligation. Left ventricular tissue samples, 4 and 30 days after I/R, were used for Western blot analysis and immunohistochemistry, respectively. Western blot analysis showed upregulation of phosphorylated Akt and GSK3-β and increased nuclear translocation of β-catenin in the PIR group versus CIR. PIR rats also indicated reduced 3-nitrotyrosine and Caspase-3 expression. Increased phosphorylation of endothelial nitric oxide synthase (p-eNOS) and upregulation of anti-apoptotic protein Bcl-2 were found in the PIR group. Echocardiography showed increased ejection fraction and fractional shortening and decreased left ventricular internal diameter in experimental subjects compared to controls. There was decreased fibrosis in P. emblica-treated rats compared to controls. The results of this study indicate that P. emblica is capable of upregulating the PI3K/Akt/GSK3β/β-catenin cardioprotective pathway, thereby preserving cardiac tissue during ischemia-reperfusion injury.

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泰国余甘子水提物中总酚含量及抗氧化活性

Cited by 22 publications

References 11 publications

Phyllanthus emblica L. Branch Extract Ameliorates Testicular Damage in Valproic Acid-Induced Rats

Phyllanthus emblica L. Branch Extract Ameliorates Testicular Damage in Valproic Acid-Induced Rats

Antioxidant Capacity and Acute Testicular Toxicity of Leucaena leucocephala Aqueous Shoot Tips Plus Young Leaves Extracts

Protective effects of Phyllanthus emblica against myocardial ischemia-reperfusion injury: the role of PI3-kinase/glycogen synthase kinase 3β/β-catenin pathway

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