Abstract:Osteoclasts are derived from the monocyte-macrophage lineage of the bone marrow and are bone-resorbing cells essential for bone homeostasis. Osteoclasts contain more mitochondria and require more oxygen to support the energy demands associated with bone resorption. However, local oxygen distribution within bone marrow has not been completely understood. Intravital two-photon microscopy is a powerful tool for investigating biological processes in live animals. In this study, we performed two-photon phosphoresce… Show more
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