フッ素化反応2010-2020

Suto, Ayane; Yamaguchi, Junichiro

doi:10.5059/yukigoseikyokaishi.79.910

Cited by 4 publications

(3 citation statements)

References 561 publications

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“…[5] For this reason, many chemical methods to introduce fluorine into molecules have been developed. [6] One of the most conventional ways of fluorination is electrophilic fluorination (Figure 2). The field has evolved with the development of various electrophilic fluorinating agents.…”

Section: Introductionmentioning

confidence: 99%

Ring‐Opening Fluorination of Carbo/Heterocycles and Aromatics: Construction of Complex and Diverse Fluorine‐Containing Molecules

Komatsuda

Yamaguchi

2023

The Chemical Record

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Fluorine‐containing molecules have attracted much attention in medicinal, agrochemical, and materials sciences because they offer unique physical and biological properties. Therefore, many efficient fluorination reactions have been developed over the years. Recent advancements in fluorination chemistry have expanded the range of substrates, and regioselectivity/stereoselectivity control has also been achieved. Ring‐opening fluorination is an efficient method to construct complex fluorine‐containing molecules with diversity, starting from simple cyclic compounds. This review aims to summarize developments in ring‐opening fluorination, particularly with larger‐sized cyclic compounds. Fluorine introduction and bond cleavage of cyclic compounds such as carbocycles, heterocycles, and aromatics provide efficient access to fluorine‐containing compounds that are difficult to be synthesized by conventional methods.

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Section: Introductionmentioning

confidence: 99%

Ring‐Opening Fluorination of Carbo/Heterocycles and Aromatics: Construction of Complex and Diverse Fluorine‐Containing Molecules

Komatsuda

Yamaguchi

2023

The Chemical Record

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“… 2 The effect of fluorine atoms in molecules has been well-studied, 3 and in turn, fluorination methodology has flourished as well. 4 One of the most conventional ways to achieve fluorination is electrophilic fluorination. Nucleophiles used in electrophilic fluorinations can be broadly classified into carbanions ( e.g.…”

Section: Introductionmentioning

confidence: 99%

Ring-opening fluorination of bicyclic azaarenes

et al. 2022

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“…Indeed, the demand for fluorinated compounds is growing in medicinal chemistry due to their higher liposolubility and metabolic stability, which renders them suitable for use in pharmaceuticals . Consequently, numerous fluorination reactions have been investigated . In particular, ring-opening fluorination, in which a fluorine atom is introduced into a cyclic compound with concomitant ring cleavage, has attracted attention in recent years.…”

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confidence: 99%

Ring-Opening Fluorination of Isoxazoles

et al. 2022

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A ring-opening fluorination of isoxazoles has been developed. Upon treatment of isoxazoles with an electrophilic fluorinating agent (Selectfluor), fluorination followed by deprotonation leads to tertiary fluorinated carbonyl compounds. This method features mild reaction conditions, good functional group tolerance, and a simple experimental procedure. Diverse transformations of the resulting α-fluorocyanoketones were also demonstrated, furnishing a variety of fluorinated compounds.

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フッ素化反応2010-2020

Cited by 4 publications

References 561 publications

Ring‐Opening Fluorination of Carbo/Heterocycles and Aromatics: Construction of Complex and Diverse Fluorine‐Containing Molecules

Ring‐Opening Fluorination of Carbo/Heterocycles and Aromatics: Construction of Complex and Diverse Fluorine‐Containing Molecules

Ring-opening fluorination of bicyclic azaarenes

Ring-Opening Fluorination of Isoxazoles

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