النشاط المضاد لتصلب الشرايين للأنيولين المستخلص من جذور الهندباء على الفئران المصابة بارتفاع کوليسترول الدم

Abstract

Atherosclerosis-associated cardiovascular diseases are main causes leading to high mortality worldwide. Hypercholesterolemic is the primary risk factor of cardiovascular disease (CVD). Inulin is considered as functional food ingredients since they affect physiological and biochemical processes in rats and human beings, resulting in better health and reduction in the risk of many diseases. The main sources of inulin that are used in the food industry are chicory. Rats were divided into two main group, the first group negative control group (5 rats) fed on basal diet for all experimental period as control negative group. Hypercholesterolemic rats were divided into 4 subgroups (5 per each): subgroup 1 served as positive control group, subgroup 2, 3 and 4 were fed basal diet and given orally one receives a daily gavage 0.25, 0.5 and 1g of inulin respectively for 30 days. After the end of experiment period, blood samples were collected for used to the biochemical analysis lipids profile and antioxidant status. The results indicated that treatments with 1g of inulin significantly (p≤0.05) improved lipid profile and compared to positive control group and other treated groups. In Conclusion :The treatment with inulin had ability to decreasing of serum and liver lipid profiles( TC, TG and TL) , LDL, VLDL-Cholesterol, fecal lipid profile and bile acid, and increase level of HDL of serum of hypercholesterolemic rats.