التأثیر العلاجی لنباتات مختلفة غنیة بالجلوتاثیون على السمیة الكبدیة و الكلویة التی یسببها الجنتامیسین فی الفئران

Abstract

The kidneys and liver are highly dependent on an adequate supply of glutathione (GSH) to maintain normal function; this is due to that it is an antioxidant that plays a big role in protecting the body from diseases. The search aimed to study the effect of different plants rich in glutathione on rats injected with gentamicin suffering from hepato-and nephrotoxicity. The study was carried out on 30 adult albino male rats Sprague-Dawley strain.Beside 6 rats served as a normal control group and 24 rats were injected with gentamicin (100 mg/kg/day for 7 days i.p) to induce hepatotoxicity and nephrotoxicity. Then, rats were the reclassified into control positive group and 3 treated rat groups that administered different doses of GSH are taken by eating rich foods from it (Asparagus and Avocado) for six weeks. The results revealed that, there was a significant decrease in blood levels of HGB, RBCs, WBCs and Serum antioxidant enzymes. There was a significant increase in cholesterol levels, LDL, HDL, triglyceride, some renal functions creatinine, Urea, uric acid, liver functions parameters AST and ALT in all treated rat groups compared with the normal control group. Group five which administered gentamicin with a high dose of GSH (1.9 mg) had a higher improvement in the final weight, weight gain, weight gain percent, feed efficiency ratio, blood levels, Serum antioxidant enzymes,cholesterol levels, renal and liver function parameters than three and four groups. All treated rat groups revealed no histopathological changes. In conclusion, intakes plants rich in glutathione helps reduce hepato-and nephrotoxicity and significantly improve kidney and liver function.