التأثیر العلاجی للکویرسیتین لدى الفئران المصابة بقرحة المعدة التی یسببها الأسبرین

Abstract

Gastric ulcer disease affects a wide range of people worldwide, and is one of the most common diseases of the twentyfirst century. This investigation was designed out to study therapeutic effects of quercetin in rats inflicted with acute gastric ulcers by aspirin. Twinty male albino rats (20010g b.wt. each) were used in the study and divided into 4 groups (n= 5 rats), one of them left as control-ve group while the rest 3 groups were once orally administered by aspirin at a dose of 200mg/kg b.wt., one of these three groups left as control +ve which fed on basal diet only and the rest twice groups orally administrated with quercetin at two doses 50 or 100 mg/kg b.wt., each for seven days as an experiment period. Gastric ulcer length, gastric juice volume, pH value, percentage of total acidity were determined, and the histopathological changes were examined. The investigation results concluded that the quercetin twice doses 50 and 100 mg/kg b.wt., had therapeutic effect for the stomachs by decreasing gastric ulcer length, gastric juice volume, percentage of total acidity, moreover, healing histopathological changes and increasing pH value of gastric juice. Furthermore, treated group with quercetin at a dose of 100 mg/kg b.wt., reflected the highest significant decrease in gastric ulcer length, gastric juice volume, percentage of total acidity with highest increase in pH value as compared to a group orally administered with a dose of 50 mg/kg b.wt. Accordingly, quercetin has a curative effect in rats infected with aspirin-induced gastric ulcer.