التأثير الحافظ لجذور وأوراق البنجر فى الفئران المصابة بخلل فى الکبد بواسطة الجنتاميسين

Abstract

The protective effect of different concentrations 5 and 10 % (Beta vulgaris, L.)as powder on gentamicin-induced nephrotoxicity and to elucidate the potential mechanism male rats was investigation. Thirty six male albino rats weighing 150±10 g were used, and divided into 6 equal groups, first one was kept as a negative (-ve) control group, while the other 5 groups wereinjected by gentamicin once day for 10 days. The obtained results concluded that the body weight gain and feed intake of all nephrotoxic rats fed on various diets showed non-significant increases in mean values as compared to positive control group.The best treatment of urea, uric acid and creatinine was recorded for rats fed on 10% beet root as compared to negative control group. The lowest liver enzymes (ALP, ALT and AST)recorded for group fed on 10% beet rootsaspowder as compared to negative control group.All nephrotoxic rats fed on different diets revealed significant decreases in total cholesterol and triglyceride with the mean values as compared to positive control group. All nephrotoxic rats fed on different diets revealed significant decrease in HDL-c, LDL-c and VLDL-c with the mean values as compared to positive control group.As conclusion, the rats fed with beat root and leaves as powder improving the kidney functions, liver functions and lipid profile.