Інтенсивна Терапія Крововтрати, Коагулопатії Та Гіповолемічного Шоку При Політравмі

Йовенко, И А; Kobeliatskyi, Yu.Yu.; Tsariov, А.V.; Kužmová, Erika; Клименко, К А; Dubovska, L.L.; Seleznyova, U.V.

doi:10.22141/2224-0586.4.75.2016.75819

Cited by 5 publications

(4 citation statements)

References 19 publications

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“…После 7 суток пребывания в стационаре анемия также может быть связана со сниженным образованием эритроцитов вследствие воспалительного процесса [2,6,7]. Развитие коагулопатии также связано с кровопотерей, гипоперфузией тканей вследствие травмы, а также с воспалением и острой активацией нейрогуморальной системы [8,9].…”

Section: Introductionunclassified

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Effect of Fresh Frozen Plasma Transfusion on Electrochemical Parameters of Blood Plasma in Patients with Severe Combined Trauma

Горончаровская¹,

Евсеев²,

Шабанов³

et al. 2020

Obŝaâ reanimatologiâ

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Purpose: to study the dynamics of blood plasma electrochemical parameters in patients with severe combined trauma before and after fresh frozen plasma (FFP) transfusions.Materials and methods. The open circuit potential (OCP) of platinum electrode and antioxidant activity of blood plasma were studied in 35 patients with severe combined trauma and 35 post-FFP samples with at least 6-month shelf life. The electrochemical parameters of patients’ blood plasma were analyzed before transfusion, and 1 hr. and 24 hrs. after transfusion.Results. OCP measured in FFP was found to be more positive vs. OCP measured in recipients' blood plasma in 34 out of 35 cases (97%). It has been shown that in patients with severe combined trauma, OCP increased from 5.047 [-7.553; 12.976] mV to 12.827 [-1.372; 24.764] mV and antioxidant activity decreased 24 hours after FFP transfusion from 16.979 [11.302; 20.946] µC to 13.551 [9.288; 18.405] µC. After FFP transfusion, there were no signiﬁcant changes in clinical blood parameters.Conclusion. By measuring electrochemical parameters of blood plasma in patients with severe combined trauma before and after FFP transfusions, it was discovered that in spite of absence of changes in blood parameters by routine methods, there are changes in the condition of the antioxidant system of the body, which manifest in the bias of patients’ blood plasma OCP towards higher positive values and decreased antioxidant activity. Redox imbalance in the body might cause the oxidative stress development.

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Section: Introductionunclassified

“…After 7-day stay in hospital, anemia might be also linked to reduced production of red blood cells due to an inflammatory process [2,6,7]. The development of coagulopathy is commonly associated with blood loss, trauma-related hypoperfusion of tissues, as well as inflammation and acute activation of the neurohumoral system [8,9].…”

Section: Introductionmentioning

confidence: 99%

Effect of Fresh Frozen Plasma Transfusion on Electrochemical Parameters of Blood Plasma in Patients with Severe Combined Trauma

Горончаровская¹,

Евсеев²,

Шабанов³

et al. 2020

Obŝaâ reanimatologiâ

View full text Add to dashboard Cite

show abstract

“…The problem of taking into account the volume of blood loss is of exceptional importance not only for choosing a strategy for any resuscitation in traumatic amputations, but also for diagnosing closed trauma and postoperative complications. The existing methods [1][2] of monitoring such blood loss are imperfect and exclude the possibility of monitoring in real time, which is critical, especially for cases of acute blood loss.…”

Section: Introductionmentioning

confidence: 99%

“…Analysis of literature sources and recent research. According to the generally accepted classification, three degrees of blood loss are distinguished: mild, moderate and severe [2,5]. Their main characteristics are given in Table 1.…”

Section: Introductionmentioning

confidence: 99%

Opportunity and Planning Bim-Analysis for Monitoring Blood

Tomashevskyi¹,

Sokol²,

Dotsenko³

2018

A.I.S.

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OPPORTUNITY AND PLANNING BIM-ANALYSIS FOR MONITORING BLOODResults of the study of the possibility of using the results of the bioimpedanceometry method for monitoring hidden and spontaneous bleeding are presented. The current problem of accounting for blood loss during resuscitation, surgery and rehabilitation activities is shown. The use, as informative parameters, of the spectral properties of the bioimpedance signal, namely, the coefficient of inter-spectral correlation of the original measurement signal and its linear transformation is proposed. In work, the existing models substantiating the prospects of using the bioimpedance method for such problems are considered in detail, and the calculated empirical expressions for determining the volume of liquid segments of the human body are given. The mathematical substantiation of the method of inter-spectral correlation based on the calculation of the correlation coefficients of the wavelet-decomposition coefficients of the original signal and its linear transformation is given. The results of experimental studies on the approbation of this method for fixed venous blood sampling are presented in the work. Using criterial T-statistics, a quantitative evaluation of the effectiveness of the options for choosing the spatial placement of measuring electrodes in bioimpedanceometry was carried out. The obtained results allow to draw a conclusion about the possibility and prospects of the proposed method for real-time monitoring of the onset of latent and spontaneous hemorrhages, and also make it possible to formulate recommendations for placement of measuring electrodes on the patient's body.

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Oxygen Regime and Exchange of Ammonia in the Sensomotor Cortex of Cats During Blood Loss and Hyperbaric Oxygenation

Яковлев

Савилов²

2020

Obŝaâ reanimatologiâ

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Purpose. To study the effect of hyperbaric oxygenation (HBO) on the oxygen regime and ammonia metabolism in the neurons of cat cortex in hemorrhagic shock.Material and methods. Experiments were performed on 164 cats (males). The effect of HBO (3 ATA, 50 min) on cerebral blood flow (CBF), oxygen tension (PO2), the content of ammonia (Am), glutamine (Gn), glutamate (Gt), α-ketglutarate (α-KG), the activity of glutamate dehydrogenase (GDG), glutamine synthetase (GS), phosphate-dependent glutaminase (PDG) activity was studied in the sensorimotor cortex (SMC); the content of Am, GN and oxygen parameters in arterial (AB) blood and venous blood (VB) of the sagittal sinus in hemorrhagic shock caused by fractional bloodletting of their femoral artery at a rate of 10ml/kg/10 min in an average volume of 24±0.8 ml/kg, which was stopped with a decrease in systolic blood pressure to the level of 60.0±1.5 mm Hg. HBO was commenced on post-hemorrhagic minute 10 following the regimen of 3 ATA for 60 min.Results. The decrease in CBF and PO2 in SMC develops as early as the 10th minute of hemorrhagic shock, progressing to the stage of hemorrhagic shock decompensation (60±14 min). Accumulation of Am in the SMC at the stage of hemorrhagic shock decompensation associated with stimulation of PDG and GDG activity, inhibition of hemorrhagic shock activity and deficiency of α-KG. HBO, without eliminating hypoxia in SMC, prevented the development of the decompensation stage in animals with GS, pathological accumulation of Am, and a decrease in the activity of hemorrhagic shock. HBO increases the Gn increment from the SMC, into the blood. Under HBO conditions, the stimulating effect of hypoxia on GDG activity remains, but the concentration of glutamate remains within the normal range, as does the activity of PDG.Conclusion. Hyperbaric oxygenation, without eliminating hypoxia in SMC, which develops in hemorrhagic shock, prevents a violation of the exchange of ammonia in it, caused by acute non-compensated blood loss.

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Інтенсивна Терапія Крововтрати, Коагулопатії Та Гіповолемічного Шоку При Політравмі

Cited by 5 publications

References 19 publications

Effect of Fresh Frozen Plasma Transfusion on Electrochemical Parameters of Blood Plasma in Patients with Severe Combined Trauma

Effect of Fresh Frozen Plasma Transfusion on Electrochemical Parameters of Blood Plasma in Patients with Severe Combined Trauma

Opportunity and Planning Bim-Analysis for Monitoring Blood

Oxygen Regime and Exchange of Ammonia in the Sensomotor Cortex of Cats During Blood Loss and Hyperbaric Oxygenation

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