The steadily increasing demand for artistic professions brings to the fore the task of studying the phenomenon of art by researching the unique capacity of the human brain to create works of art in different spheres of creative activity. So far, only a few studies have investigated creativity-related brain activity in representatives of the creative professions. The aim of the empirical research was to study the neurophysiological correlates of artistic image creation by representatives of the artistic professions. The participants were 60 right-handed females aged 23-27, divided into three groups-artists (23 people), actors (17 people), and specialists who do not work in an artistic field (20 people). The mono-typing technique was used to model the creative artistic process. EEG signals were recorded in a resting state, and during four stages of the creation of an artistic image (viewing of monotypes, frustration, image creation, and thinking over the details) from 21 electrodes set on the scalp according to the International 10-20 System. We analyzed EEG coherence for each functional trial at theta (4.00-8.00 Hz), alpha1 (8.00-10.5 Hz), alpha2 (10.5-13.00 Hz), and beta (13.00-35.00 Hz) frequency bands. For statistical analysis, we used MANOVA and post hoc analysis. We found that the neurophysiological correlates of creating an artistic image are different at different stages of the creative process, and have different features for artists and actors. The actors primarily show dominance of right hemisphere activity, while close interaction of the hemispheres distinguishes the brains of the artists. The differences revealed in brain cortex functioning when artists or actors create an artistic image reflect different strategies of imaginative creative work by representatives of these professions.