Структурні Порушення Колінного Суглоба При Моделюванні Остеоартрозу

Tkachuk, P.V.; Страфун, С.С.; Savosko, S.I.; Макаренко, О. М.

doi:10.22141/1608-1706.1.20.2019.158673

Cited by 5 publications

(2 citation statements)

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“…На фоне длительно сохраняющегося провоспалительного потенциала тканей сустава происходит значительное снижение репаративных процессов, что в конечном итоге приводит к дезорганизации внеклеточного матрикса и прогрессирующей дезинтеграции хряща в совокупности с другими дегенеративно-дистрофическими внутрисуставными изменениями [4].…”

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Changes of the cytokine profile in patients with traumatic synovitis on the background of ozone therapy

Захватов

Тарасова

Виноградова

et al. 2020

Science and Innovations in Medicine

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Objectives the cytokine profile research in patients with posttraumatic synovitis during intravenous and intra-articular ozone therapy. Material and methods.The research involved 69 patients with traumatic knee joint damage complicated by posttraumatic synovitis. Patients in Group I (35 people) received a traditional treatment. Patients in Group II (34 people) along with the traditional therapy had intravenous injection of 200 ml of ozonated solution of sodium chloride in ozone concentration 2 mg/l once daily for 10 days, and intra-articular injection of 20 ml ozone-oxygen mixture in ozone concentration of 15 mg/l once every second day, in an amount of 5 injections. During arthroscopy, the lavage of the joint cavity was performed with ozonated saline solution at a concentration of 2.0 mg/l. The cytokine profile was evaluated by the content of pro-inflammatory cytokines (TNF-, IL-1, IL-6, IL-17), regulatory (IL-2), IL-1 receptor antagonist, and anti-inflammatory (IL-4, IL-10) cytokines by solid-phase enzyme immunoassay with peroxidase as an indicator. Statistical analysis of the results was carried out using the Student t-test. Results.The use of intravenous and intra-articular ozone therapy contributed to synchronous decrease of the levels of pro-inflammatory cytokines with simultaneous reduction of anti-inflammatory mediators of inflammation. TNF-content decreased by 24.6% (p20.001), IL-17 by 17.3% (p20.01), IL-6 by 20.1% (p20.001), IL-1 by 19.1% (p20.001), IL-2 by 25.7% (p20.001), IL-1RА by 24.4% (p20.001), IL-10 by 21.3%(p20.001), IL-4 by 25.7% (p20.001) in comparison to traditional treatment. Conclusion.The complex ozone therapy led to the decrease of inflammation, which was reflected in the depression dynamics of the studied cytokines. These results allow us to evaluate it as an effective treatment method for post-traumatic synovitis which effectively reduces the secondary posttraumatic alteration of tissue structures.

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Section: Discussionunclassified

Changes of the cytokine profile in patients with traumatic synovitis on the background of ozone therapy

Захватов

Тарасова

Виноградова

et al. 2020

Science and Innovations in Medicine

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“…За даними Всесвітньої організації охорони здоров'я, в найближчі 10-15 років остеоартроз (ОА) стане четвертою за частотою причиною інвалідності у жінок, та восьмоюу чоловіків [3]. На даному етапі досліджень остеоартроз розглядається як комплексне захворювання, при якому до процесу залучаються усі структурні компоненти суглоба [4,5]. Ряд авторів визначає ОА, як гетерогенну групу захворювань різної етіології із тотожними клінічними, морфологічними та функціональними проявами, в основі якихпошкодження хряща, субхондральної кістки, синовіальної оболонки, зв'язок, капсули та навколосуглобових м'язів [6,7].…”

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Dynamics of Interleukin-1β and Inducible NO-Synthase Activities in Blood of Rats in Experimental Osteoarthritis

Savytskyi¹,

Orel²,

Miastkivska³

et al. 2019

Ukr. ž. med. bìol. sportu

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Вплив Препаратів Кріоконсервованої Плаценти На Перебіг Неспецифічного Гонартриту В Експерименті

Pelypenko¹,

Шепітько²

2021

TRAUMA

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Background. Treatment of joint pathology, both degenerative and traumatic, is a long, multicomponent process that requires joint efforts of the doctor and the patient. The choice of the optimal therapy is complex and ambiguous. Biologically active compounds are one of the most powerful things for fighting with inflammatory process, which is a constant companion of dama-ge. Due to their antioxidant, immunomodulatory and regenerative properties, placental fragments were admitted as a perspective treatment for arthropathies of various etiologies. Purpose of the research: to determine the morphological characteristics of the constituent structures of the knee joints of rats in a comparative aspect under normal conditions, in experimental arthritis and after exposure to a cryopreserved placenta. Material and methods. An experimental study was carried out on 115 white rats. With the intact group (10 animals) we compared 3 control groups of 35 animals each, who underwent: 1) modeling of carrageenan-induced aseptic inflammation of the knee joint; 2) subcutaneous implantation of placental fragment; 3) subcutaneous implantation of placental fragment against the background of aseptic inflammation of the knee joint. Histological preparations were prepared according to the general methods with hematoxylin-eosin and Van Gieson staining. Results. During the creating an inflammatory focus, changes in the cartilaginous tissue were determined from day 3 in the form of lacunarity, karyopyknosis as a stage of necrobiosis of chondrocytes, especially pronounced on days 10–14. Morphological changes in the bone tissue of rats, which were injected λ-carrageenan, were noted on the 7th day of the research in the form of resorption and destruction of bone trabeculae. Later (day 10), the inflammatory process led to a picture of the fragmented architectonics of bone tissue, which was observed up to 21 days. From the side of the synovial membrane, villous hyperplasia, lymphoid infiltration, and the appearance of additional layers of synoviocytes were observed as a result of a proliferative reaction. The most pronounced changes were observed in the integumentary layer of the synovium. After a single injection of a cryopreserved placenta, the signs of inflammation significantly decreased: the area of destruction of cartilage and bone was limited, and signs of mucoid swel-ling in the synovium decreased. Processes of functional blood filling of the microvasculature prevailed over ischemic ones. Stimulation of regenerative processes provided structural recovery on day 21 of observation. Conclusions. Prepartions of cryopreserved placenta influence the course of the inflammatory process in experimental osteoarthritis. The most reliable therapeutic effect is determined from the side of the synovium.

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Структурні Порушення Колінного Суглоба При Моделюванні Остеоартрозу

Cited by 5 publications

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Changes of the cytokine profile in patients with traumatic synovitis on the background of ozone therapy

Changes of the cytokine profile in patients with traumatic synovitis on the background of ozone therapy

Dynamics of Interleukin-1β and Inducible NO-Synthase Activities in Blood of Rats in Experimental Osteoarthritis

Вплив Препаратів Кріоконсервованої Плаценти На Перебіг Неспецифічного Гонартриту В Експерименті

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