Сравнительный анализ функциональных характеристик аппарата «Cooltech®» для криоадиполиза методом численного моделирования

Viera-Mármol, Gregorio; Villena, Jorge Fernández; García, Pablo Naranjo; Khrystova, Kristina; Colina, M.

doi:10.15407/cryo28.04.343

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…To avoid damage to the human body caused by low temperature, an antifreeze film specially designed for cryolipolysis has been developed and applied to the surface of the treated skin. Adding a cryoprotectant to the antifreeze film to protect the skin from being damaged by low temperature during the treatment process 19 . The cold source temperature in the simulation was defined as −10°C 20 …”

Section: Methodsmentioning

confidence: 99%

“…Adding a cryoprotectant to the antifreeze film to protect the skin from being damaged by low temperature during the treatment process. 19 The cold source temperature in the simulation was defined as −10°C. 20 Fat crystallization is considered to be the main cause of inflammation in adipocytes, but the effect of fat crystals was ignored in this study because the thermogenic behavior of fat crystals has little effect on the heat transfer process of cryolipolysis.…”

Section: Governing Equations and Boundary Conditionsmentioning

confidence: 99%

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Structural design optimization and lipolytic effect prediction of vacuum suction cryolipolysis applicator: Simulation study

et al. 2023

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Background and Objectives: Cryolipolysis is a popular noninvasive lipolytic method that uses low temperature to induce apoptosis or necrosis of adipocytes to reduce local fat in the human body. Vacuum suction applicator is a commonly used cryolipolysis equipment, which suction human skin and fat into a chamber for cooling. The structure of vacuum suction applicator is usually irregular, its cooling characteristic is also complex, and unreasonable suction structure will cause human discomfort. Biological experiments and clinical studies are often used to study the structural design of applicators, whereas these methods are impossible to obtain the three-dimensional cooling characteristic of applicator comprehensively and require a lot of costs. This study aims to optimize the structure of applicator for lowering discomfort, evaluate the cooling characteristic and lipolytic effect of applicators, which could provide guidance for clinical application of applicators and reduce costs. Materials and Methods: Cryolipolysis applicators models with four vacuum suction angles were established, and COMSOL was used to compare the cooling performance parameters, cooling kinetics, and lipolytic effects of the applicators. Specific evaluation indicators also include: cooling capacity analysis, temperature field analysis, lipolytic percentage, lipolytic volume, lipolytic weight, lipolytic thickness, lipolytic waistline, and lipolysis temperature threshold analysis. Results: The applicator with a small suction angle has a greater cooling capacity to cool deeper level of fat. When the cooling temperature is −10°C, the temperature of skin layer is about −10°C at 60 minutes, the temperature of fat layer is −7.36 to 3.01°C at 10 mm, −3.67 to 5.91°C at 20 mm and 2.01−10.81°C at 30 mm. The percentage of lipolytic declined with the increase of suction angle, the final lipolytic percentage (35.81%) of the 90°applicator is the highest, the percentage (28.72%) of 150°applicator (28.72%) is the lowest. The lipolytic volume, weight, and average thickness of applicator constantly increased with the increase of the suction angle, the final lipolytic volume range of the four suction angle applicators is 171.88−310.18 cm 3 , the lipolytic weight range is 160.11−288.93 g, and the lipolytic average thickness range is 1.21−1.36 cm. Lower lipolysis temperature threshold will reduce the lipolysis effect, but it may also lead to another lipolysis mechanism-cell necrosis. Conclusion: Different suction angles significantly affect the cooling characteristics and lipolytic effects of cryolipolysis applicator. A reasonable suction angle is one of the critical factors to improve the efficiency and comfort of cryolipolysis.

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Section: Methodsmentioning

confidence: 99%

Section: Governing Equations and Boundary Conditionsmentioning

confidence: 99%

Structural design optimization and lipolytic effect prediction of vacuum suction cryolipolysis applicator: Simulation study

et al. 2023

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“…The device works by applying suction and then cooling the treatment area to induce apoptosis of adipocytes. 17 Newer Cooltech Define Applicators are superior to previous Cooltech applicators, as they cool a larger percentage of internal tissue more homogeneously. 18 A study at Cocoon Medical Laboratories evaluated the 360°Cooltech Define Applicators compared to the previous Cooltech applicators.…”

Section: Adverse Events/complicationsmentioning

confidence: 99%

Cryolipolysis—An update

Pennycook

Lemchak

Julian

2020

Dermatological Reviews

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Background: Cryolipolysis is a noninvasive treatment for the reduction of localized adipose tissue. It is becoming an increasingly popular procedure since it received Food and Drug Administration approval in 2010. Localized collections of excess adipose tissue are cooled which results in selective apoptosis of adipocytes. Aims: Review of effectiveness and side effects of cryolipolysis treatments. Materials and Methods: Literature Review. Results: Studies have demonstrated the effectiveness of cryolipolysis for the treatment of several body regions. Cryolipolysis is contraindicated for patients with cold-induced conditions and other cutaneous disorders. Most side effects are minor including erythema and local discomfort which typically resolve within a few weeks of the procedure. A rare complication of treatment is paradoxical adipose hyperplasia. Discussion: There are several other effective noninvasive modalities for reducing localized adipose tissue. Combining these treatments with cryolipolysis has been shown to be more effective. As technology improves, newer devices have been developed with improved applicators and beneficial results. Conclusion: Cosmetic procedures continue to increase in popularity and physicians should be familiar with cryolipolysis for the reduction of localized adipose tissue collections.

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From Simulation to Reality: A Comprehensive Study on the Efficacy of a Rotating Monopolar and Bipolar Radiofrequency System through <i>In-Silico</i> Modeling and Pre-Clinical and Clinical Validation

Mármol,

Bojorge,

Jorge

et al. 2024

JBiSE

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Сравнительный анализ функциональных характеристик аппарата «Cooltech®» для криоадиполиза методом численного моделирования

Cited by 3 publications

References 7 publications

Structural design optimization and lipolytic effect prediction of vacuum suction cryolipolysis applicator: Simulation study

Structural design optimization and lipolytic effect prediction of vacuum suction cryolipolysis applicator: Simulation study

Cryolipolysis—An update

From Simulation to Reality: A Comprehensive Study on the Efficacy of a Rotating Monopolar and Bipolar Radiofrequency System through <i>In-Silico</i> Modeling and Pre-Clinical and Clinical Validation

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