Сравнение Эффектов Моделирования Септопластики И Синус-Лифтинга У Крыс На Изменение Вариабельности Сердечного Ритма

Драгунова, С. Г.; Решетов, И. В.; Косырева, Т. Ф.; Северин, А. Е.; Хамидулин, Г. В.; Шмаевский, П. Е.; Иноземцев, А. Н.; Попадюк, В. И.; Кастыро, И. В.; Юдин, Д. К.; Юнусов, Т. Ю.; Клейман, В. К.; Багдасарян, В. В.; Алиева, С. И.; Чудов, Р. В.; Кузнецов, Н. Д.; Пинигина, И. В.; Скопич, А. А.; Костяева, М. Г.

doi:10.31857/s2686738921030045

Cited by 2 publications

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“…Таким образом, воспалительные процессы в полости носа и околоносовых пазухах при хроническом риносинусите характеризуются не только назальной обструкцией и нарушением обоняния, но и сложными процессами в центральных отделах нервной системы: в гипоталамогипофизарном комплексе нарушают функционирование вегетативной нервной системы, что опосредованно влияет на носовую полость, влечет вторичные изменения и усугубляет патогенетический круг [17][18][19].…”

Section: Discussionunclassified

Morphological changes in the neuroepithelium of the olfactory zone of the nasal cavity in patients with chronic polypous rhinosinusitis

Elizbaryan,

Lazareva,

Chuprinenko

et al. 2024

Medicinskij sovet

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Introduction. The polymorphism of clinical manifestations of chronic polypous rhinosinusitis determines the need for a detailed scientific approach in the study of pathogenetic mechanisms.Aim. To study the morphological manifestations of disorders of the neuroepithelium of the olfactory zone of the nasal cavity in patients with chronic polypous rhinosinusitis.Materials and methods. We conducted a prospective analysis of biopsic specimens as well as clinical and functional parameters of 16 patients with chronic polypous rhinosinusitis, who were divided into two groups: treatment group (A) and comparison group (B), aged 25 to 65 years (average age 53 ± 14.3 years). The study subset included 7 men and 9 women. We assessed the main clinical manifestations: radiologic abnormalities in the nasal cavity and paranasal sinuses evaluated according to the Lund-Mackay score, olfactometry and MoCA test in addition to a pathomorphological examination of olfactory neuroepithelium biopsied from the nasal cavity and determination of the chronic inflammation activity index using a histological activity score.Results. In all patients with chronic polypous rhinosinusitis in the symptom complex, there was a violation of the sense of smell in the variants of hyposmia (50%) and anosmia (50%). The presence of neurocognitive disorders according to the MOS test was detected in 70% of patients. During morphological examination, pathological disorders in the olfactory zone of the nasal cavity were caused by atrophy of nerve fibers and lympho-macrophage infiltration involving mixed glands (variable range – mild/moderate/severe). All the analyzed signs were directly dependent on the duration of the disease and the severity of the lesion.Discussion. Analysis of radiologic findings according to the Lund-MacKay score combined with the age of the patients and duration of the disease confirms the rationale of conducted study and its topicality.Conclusion. The revealed pathological changes in the neuroepithelium of the nasal cavity in the olfactory zone were observed only in patients with chronic polypous rhinosinusitis and were directly dependent on the duration of the disease and the form of the inflammatory process.

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Section: Discussionunclassified

Morphological changes in the neuroepithelium of the olfactory zone of the nasal cavity in patients with chronic polypous rhinosinusitis

Elizbaryan,

Lazareva,

Chuprinenko

et al. 2024

Medicinskij sovet

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“…ГГМ можно лечить как хирургическим способом (аденотомия), так и консервативно (топические назальные глюкокортикоиды) [3][4][5][6]. Правильная и своевременная диагностика патогенеза развития ГГМ необходима для верного выбора тактики лечения этого заболевания, так как хирургический метод не всегда необходим и в случае аллергической природы ГГМ может привести не только к викарной гипертрофии трубных миндалин, но и к развитию хирургического стресса, что было показано в ряде экспериментальных [7][8][9][10] и клинических исследований [11][12][13][14].…”

Section: Introductionunclassified

<i>G-1082A</i> IL-10 polymorphism as a predictor of adenoid hypertrophy in children with human herpes virus

et al. 2023

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Introduction. Adenoid hypertrophy (pharyngeal tonsil hypertrophy) is considered as one of the most common diseases of the ENT organs.Aim. To study the polymorphism of the IL-10 gene (interleukin 10) and infections caused by human herpesvirus 6 (HHV6), cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in children with AH.Materials and methods. The study included 106 children with adenoid hypertrophy and 38 healthy children aged 2 to 11 years. All children with adenoid hypertrophy were divided into three subgroups depending on the size of the pharyngeal tonsil. Viruses were determined by real-time quantitative polymerase chain reaction (PCR).Results. In patients with AH, HHV6 was detected more often than in CMV and EBV. Among the three subgroups of children with HGM, HHV6 and EBV infections prevailed in children with the maximum degree of pharyngeal tonsil hypertrophy. The frequency of the GG genotype was higher in the control group of children. Significantly higher frequencies of the G allele and GG and GA genotypes for IL-10 rs1800896 were found in the subgroup of children with the smallest size of the pharyngeal tonsil compared to other subgroups.Discussions. The frequencies of HHV-6 and CMV in the control group are significantly different. HHV-6 was the most frequently detected virus in patients with HGM compared with CMV and EBV. The frequency of the GG genotype was in the control group of children. A significantly higher frequency of the G allele and GG genotypes was found in the first subgroup of children compared to the second and exclusive subgroups. We found a lower frequency of the G allele and GG and GA genotypes in a significant subgroup of children compared to the second subgroup. Previous studies show a significant increase in the frequency of the A allele and the AA and IL-10 genotypes (rs1800896-1082G/A) in patients resistant to HHV-6 and CMV infections compared to those infected.Conclusions. The presence of HHV-6 and CMV infections contributes to the development of pharyngeal tonsil hypertrophy, and HHV-6 and EBV may contribute to the size of the pharyngeal tonsil.

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Сравнение Эффектов Моделирования Септопластики И Синус-Лифтинга У Крыс На Изменение Вариабельности Сердечного Ритма

Cited by 2 publications

References 0 publications

Morphological changes in the neuroepithelium of the olfactory zone of the nasal cavity in patients with chronic polypous rhinosinusitis

Morphological changes in the neuroepithelium of the olfactory zone of the nasal cavity in patients with chronic polypous rhinosinusitis

<i>G-1082A</i> IL-10 polymorphism as a predictor of adenoid hypertrophy in children with human herpes virus

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