Синтез и биологическая активность нового 3,3'-диметилпроизводного
            <i>
              L
            </i>
            -селеноцистина

Полубояринов, П А; Golubkina, Nadezhda; Аниськов, А. А.; Моисеева, И. Я.; Глебова, Н. Н.; Швец, В. И.

doi:10.1134/s0132342319040080

Cited by 2 publications

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“…Селенит и селенат натрия. Неорганические соединения -селенат, селенит натрия вступают в неферментативную реакцию с восстановленным глутатионом (GSH) с образованием селенодиглутатиона (GS-Se-SG) [ Наши исследования показали, что интермедиат селенодиглутатион присутствует в реакционной смеси в незначительных количествах [34], нестабилен [35] и не может служить полноценным обменным пулом (буфером) для организма.…”

Section: серы металлический селен -самая термодинамически устойчиваяunclassified

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Metabolism and Mechanism of Toxicity of Selenium-Containing Supplements Used for Optimizing Human Selenium Status

Poluboyarinov

Elistratov²,

Shvets

2019

Fine Chem. Tech.

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The work presents a review devoted to the metabolism and the mechanism of toxicity of seleniumcontaining supplements: elemental selenium, sodium selenite, diacetophenonyl selenide, selenopyrane, ebselen, dimethyl dipyrasolyl selenide and selenium-containing amino acids used for correction of selenium deficiency. Elemental selenium penetrating through cell walls, but not through transport channels demonstrates poorly predicted and difficultly regulated bioavailability. Sodium selenate is known to be the most toxic form of selenium in food. The metabolism of xenobiotic diacetophenonyl selenide resembles that of sodium selenide. The xenobiotic reacts with thiols, for instance, with the reduced form of glutathione leading to the formation of hydrogen selenide. Ebselen is not considered to be a well bioavailable form of selenium and thus possesses low toxicity. Xenobiotic selenopyrane eliminates selenium only in processes of xenobiotic liver exchange, and in our investigations - partially in acid-catalyzed hydrolysis. The metabolism of xenobiotic dimethyl dipyrasolyl selenide having low toxicity is poorly investigated. The toxicity of high doses of selenomethionine is determined by the possibility of incorporation in proteins and vitally important enzymes with dramatic changes of protein quaternary structure. The toxicity of high doses of methylselenocysteine seems to be caused by the lack of an exchange pool in the body and quick regeneration of hydrogen selenide from methylselenol which is formed as a result of enzymatic destruction of this amino acid. Also the issue of the most prospect selenium donor is discussed. The physiological compatibility, the low toxicity, the presence of an exchangeable pool in the organism, the antioxidantal properties and the simplicity of production indicate selenocystine as an optimal selenium donor.

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Section: серы металлический селен -самая термодинамически устойчиваяunclassified

“…Отмечается, что данная реакция проходит в тонком кишечнике [77,78]. Наличие Seс-SG определяется хроматографически [34].…”

Section: схема 3 общая схема метаболизма селенсодержащих ксенобиотиковunclassified

Metabolism and Mechanism of Toxicity of Selenium-Containing Supplements Used for Optimizing Human Selenium Status

Poluboyarinov

Elistratov²,

Shvets

2019

Fine Chem. Tech.

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Induction of the Antioxidant Activity by Selenium Compounds in the <i>Aspergillus niger</i> Mycelium

Poluboyarinov,

Kuznetsova,

Moiseeva

et al. 2023

RUBI

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Investigation of the antioxidant activity (AOA) induction by selenium compounds (Na2SeO3, diacetophenonyl selenide (DAPS-25), L-selenocystine) in various organisms is interesting as a protection from stress induced cell membranes damages. A comparative analysis of the antioxidant activity of 23 amino acids was performed by coulometric titration with electrogenerated bromine and iodine. The activity decreases in the order: cystine tryptophan selenocystine tyrosine 3,3'-dimethyl-L-selenocystine methionine. Only amino acids with sulfhydryl and selenol groups as more active reductants can interact with the electrogenerated iodine: cysteine selenocysteine threo-3-methyl-L-selenocysteine. Probably the correction of the antioxidant status at the amino acids level is based on the sulfhydryl and selenol groups in radicals. In case they are not enough, cystine, selenocystin, tryptophan, tyrosine, and methionine will act as scavenger-reductants. It was found that selenium compounds dose-dependently induce the total antioxidant activity of the A. niger mycelium and affect indicators of the antioxidant status (amino acid composition and catalase activity), which in turn stimulates the biomass accumulation. DAPS-25 and sodium selenite treatment at the high doses (0.025 mg Se/L) caused the greatest effect on the total AOA induction (3.4–5.5 times). Lower concentrations (0.0025–0.00025 mg Se/L) had a lesser effect (25.8–41.7%). Activity in samples with L-selenocystin increased by 1.6–43.3%. It is noted that the iodine antioxidant activity in the mycelium was generally lower than the bromine one.

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Синтез и биологическая активность нового 3,3'-диметилпроизводного L -селеноцистина

Cited by 2 publications

References 0 publications

Metabolism and Mechanism of Toxicity of Selenium-Containing Supplements Used for Optimizing Human Selenium Status

Metabolism and Mechanism of Toxicity of Selenium-Containing Supplements Used for Optimizing Human Selenium Status

Induction of the Antioxidant Activity by Selenium Compounds in the <i>Aspergillus niger</i> Mycelium

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