сWnt signaling modulation results in a change of the colony architecture in a hydrozoan

Lebedeva, Tatiana; Kupaeva, Daria M.; Vetrova, Alexandra A.; Kosevich, I. A.; Kraus, Yulia; Kremnyov, Stanislav

doi:10.1016/j.ydbio.2019.08.019

Cited by 13 publications

(23 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To study the specification of germ layers and its dynamics in the embryonic development of D. pumila , we visualized the expression of FoxA and Snail, known endodermal markers in hydrozoans (Lapébie et al, 2014; Kraus et al, 2015; Bagaeva et al, 2019; Kraus et al, 2020). For example, their expression is colocalized with an oral region at the beginning of polar gastrulation in C. hemisphaerica (Kraus et al, 2020).…”

Section: Resultsmentioning

confidence: 99%

“…The first description of D. pumila development was performed by Teissier (1923). Since then, D. pumila regularly comes under scrutiny: embryonic development and molecular aspects of colony formation were previously investigated (Kraus, Cherdantsev, 2003; Kraus, 2006; Bagaeva et al, 2019). However, embryonic cell ultrastructure, the molecular basis of morphogenesis, and body axis formation have not been explored in sufficient detail throughout the development of D. pumila .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Apolar mode of gastrulation leads to the formation of polarized larva in a marine hydroid,Dynamena pumila

Vetrova

Lebedeva

Saidova

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Background: In almost all metazoans examined to this respect, the axial patterning system based on canonical Wnt (cWnt) signaling operates throughout the course of development. In most metazoans, gastrulation is polar, and embryos develop morphological landmarks of axial polarity, such as blastopore under control/regulation from Wnt signaling. However, in many cnidarian species, gastrulation is morphologically apolar. The question remains whether cWnt signaling providing the establishment of a body axis controls morphogenetic processes involved in apolar gastrulation. Results: In this study, we focused on the embryonic development of Dynamena pumila, a cnidarian species with apolar gastrulation. We thoroughly described cell behavior, proliferation, and ultrastructure and examined axial patterning in the embryos of this species. We revealed that the first signs of morphological polarity appear only after the end of gastrulation, while molecular prepatterning of the embryo does exist during gastrulation. We have shown experimentally that in D. pumila, the morphological axis is highly robust against perturbations in cWnt activity. Conclusion: Our results suggest that morphogenetic processes are uncoupled from molecular axial patterning during gastrulation in D. pumila. Investigation of D. pumila might significantly expand our understanding of the ways in which morphological polarization and axial molecular patterning are linked in Metazoa.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Apolar mode of gastrulation leads to the formation of polarized larva in a marine hydroid,Dynamena pumila

Vetrova

Lebedeva

Saidova

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Strikingly, the phenotypic effects of Wnt3 upregulation mimics colony form in other leptothecate species (Bagaeva et al, 2019). Hensel et al (2014) identified several Wnt genes to be expressed in the stolons of Hydractinia echinata, with the ligand Wnt11a appearing to be specific to this particular structure.…”

Section: Developmental Mechanisms Dictating Colonial Morphogenesismentioning

confidence: 99%

“…A recent study by Bagaeva et al (2019) documented the expression of the canonical Wnt pathway (Wnt3 and downstream components) in the leptothecate hydrozoan Dynamena pumila. D. pumila displays monopodial upright growth with symmetrical budding of polyps along a growing shoot.…”

Section: Developmental Mechanisms Dictating Colonial Morphogenesismentioning

confidence: 99%

The evolution and development of coloniality in hydrozoans

2020

View full text Add to dashboard Cite

Hydrozoan colonies display a variety of shapes and sizes including encrusting, upright and pelagic forms. Phylogenetic patterns reveal a complex evolutionary history of these distinct colony forms, as well as colony loss. Within a species, phenotypic variation in colonies as a response to changing environmental cues and resources has been documented. The patterns of branching of colony specific tissue, called stolons in encrusting colonies and stalks in upright colonies, are likely under the control of signaling mechanisms whose changing expression in evolution and development are responsible for the diversity of hydrozoan colony forms. Although mechanisms of polyp development have been well studied, little research has focused on colony development and patterning. In the few studies that investigated mechanisms governing colony patterning, the Wnt signaling pathway has been implicated. The diversity of colony form, evolutionary patterns and mechanisms of colony variation in Hydrozoa are reviewed here.

show abstract

“…Although considerable insight has been gained in the patterning of hydrozoan polyps, much less is known about the developmental mechanisms underlying colony formation (although see Cartwright et al, 2006, Hensel et al, 2014, and Bagaeva et al, 2019. The Wnt pathway is a good candidate given that it plays a prominent role in patterning the polyp (Hobmayer et al, 2000;Momose and Houliston, 2007;Müller et al, 2007;Plickert et al, 2006), medusa (Momose and Houliston, 2007;Sanders and Cartwright, 2015a), and more recently, colony form (Hensel et al, 2014;Bagaeva et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Frizzled3 expression and colony development in hydractiniid hydrozoans

2020

View full text Add to dashboard Cite

Hydractiniid hydrozoan colonies are comprised of individual polyps connected by tube-like stolons or a sheet-like mat. Mat and stolons function to integrate the colony through continuous epithelia and shared gastrovascular cavity. Although mechanisms of hydrozoan polyp development have been well studied, little is known about the signaling processes governing the patterning of colonies. Here we investigate the Wnt receptor family Frizzled. Phylogenetic analysis reveals that hydrozoans possess four Frizzled orthologs. We find that one of these genes, Frizzled3, displays a spatially restricted expression pattern in colony specific tissue in two hydractiniid hydrozoans, Hydractinia symbiolongicarpus and Podocoryna carnea, in a manner that corresponds to their distinct colony forms (stolonal mat in Hydractinia and free stolons in Podocoryna). Interestingly, Frizzled3 was lost in the genome of Hydra, which is a solitary polyp and thus lacks colony specific tissue. Current evidence suggests that the Wnt signaling pathway plays a key role in the evolution of colony diversity and colony loss in Hydrozoa. BS ≥ 90 90 > BS ≥ 80 80 > BS ≥

show abstract

сWnt signaling modulation results in a change of the colony architecture in a hydrozoan

Cited by 13 publications

References 29 publications

Apolar mode of gastrulation leads to the formation of polarized larva in a marine hydroid,Dynamena pumila

Apolar mode of gastrulation leads to the formation of polarized larva in a marine hydroid,Dynamena pumila

The evolution and development of coloniality in hydrozoans

Frizzled3 expression and colony development in hydractiniid hydrozoans

Contact Info

Product

Resources

About