Роль Изменений Окислительно-Восстановительных Реакций В Патогенезе Эндотелиальной Дисфункции Разной Степени Тяжести При Артериальной Гипертонии

Горшунова, Н. К.; Медведев, Н. В.; Rakhmanova, O.V.

doi:10.21626/vestnik/2018-2/03

Cited by 3 publications

(1 citation statement)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on the literature data obtained, it can be assumed that the study of innate immunity indices in patients with arterial hypertension in clinical trials may lead us to the need for their correction in order to reduce vascular inflammation in arterial hypertension to prevent damage to target organs and the development of complications of the cardiovascular system (Gertsev et al 2017;Dzekh et al 2018), and initially it is necessary to establish the effectiveness of antihypertensive pharmacotherapy in the correction of innate immunity indices in patients with essential arterial hypertension.…”

Section: Introductionmentioning

confidence: 99%

Antihypertensive Pharmacotherapy in Correcting the Indicators of Innate Immunity in Patients with Essential Arterial Hypertension

Gavriliouk¹,

Evsegneeva²,

Михин³

2020

RRP

View full text Add to dashboard Cite

Introduction: The study of indicators of innate immunity in patients with arterial hypertension in clinical trials makes it necessary to correct them in order to reduce vascular inflammation in arterial hypertension to prevent damage to target organs and development of cardiovascular complications. The aim of the study was to assess the effectiveness of antihypertensive therapy to correct indicators of innate immunity in patients with essential arterial hypertension. Materials and methods: Patients with essential arterial hypertension (EAH) (II stage, 3rd degree) were divided into 3 groups: the 1st group included the patients with hypertrophy of the left ventricular myocardium; the 2nd group included the patients with atherosclerotic vascular lesions; the 3rd group included the patients with chronic kidney disease. As an initial antihypertensive pharmacotherapy, all the patients with essential arterial hypertension were prescribed perindopril (5–10 mg/day) and amlodipine (5–10 mg/day). Results and discussion: Changes in innate immunity indices in patients with essential arterial hypertension (II stage, 3rd degree) are differentiated depending on the affected target organ. The antihypertensive pharmacotherapy with perindopril and amlodipine in patients with essential arterial hypertension has various corrective effects on impaired innate immunity, depending on the nature of target organ damage. Regardless of target organ damage, ноу antihypertensive therapy with perindopril and amlodipine does not affect the reduced functional and increased metabolic activities of peripheral blood neutrophils. Conclusion: The results obtained dictate the need for further clinical studies of other classes of antihypertensive drugs and their combinations in the correction of innate immunity indices in order to effectively prevent the progression of target organ damage. Graphical abstract

show abstract

Section: Introductionmentioning

confidence: 99%

Antihypertensive Pharmacotherapy in Correcting the Indicators of Innate Immunity in Patients with Essential Arterial Hypertension

Gavriliouk¹,

Evsegneeva²,

Михин³

2020

RRP

View full text Add to dashboard Cite

show abstract

Endothelial function in benign and progressive course of periferal arterial disease

Kalinin¹,

Suchkov²,

Chobanyan³

et al. 2021

Kardiol. serdechno-sosud. khir.

View full text Add to dashboard Cite

The influence of harmful physical factors and industrial dust on changes in some biochemical and functional indicators of the cardiovascular system and respiratory system in workers engaged in underground mining of ore

Александровна

Koldibekova²,

Ukhabov³

2019

Myditsina truda I promyshlennaya ekologiy

View full text Add to dashboard Cite

Introduction. The health of workers is determined by both social and individual, as well as production factors, including noise, vibration and dust, characteristic of technological processes in mining enterprises. Industrial noise above 90 dBA and dust in the form of suspended and fine particles causes dysfunction of the cardiovascular system and respiratory organs.The aim of the study is to assess the impact of harmful physical factors and industrial dust on changes in some biochemical and functional indicators of the cardiovascular system and respiratory system of employees of the enterprise for underground mining of ore.Materials and methods. The assessment of working conditions of workers engaged in underground mining and processing of chrome ores, the analysis of industrial dust on the dimension and quantitative content of fine particles PM10 and PM2. 5, the study of biochemical parameters of lipid metabolism, oxidant and antioxidant systems, indicators of respiratory function. Results. Harmful working conditions (class 3.1–3.4) in terms of noise and vibration were revealed at the workplaces of employees of the main specialties observation group. In the air of the working zone, the highest content of fine particles PM2.5 (2.68±0.54 mg/m3) and PM10 (4.64±0.93 mg/m3) was established at the site of drilling operations and cleaning of the bottom-hole space. Deviations of biochemical parameters characterizing intensification of free radical processes and antioxidant protection, imbalance of lipid spectrum parameters, and violation of functional parameters of external respiration were revealed. A high degree of connection with the working conditions of the frequency of increased levels of lipid hydroperoxide and antioxidant activity (EF=60.71–65.84%) was established.Conclusions. In high noise level (more than 94 dBA), general and local vibration (more than 116 and 127 dB respectively) and the content of fine particles PM2. 5 (more of 2.14 mg/m3) and PM10 (over of 3.71 mg/m3) at underground mining of chrome ore workers have identified abnormalities in the form of increase 1.6 times the level of lipid hydroperoxides and total antioxidant activity, reducing to 1.2 times the level of high density lipoprotein, improving 1.2–1.3 times of low-density lipoproteins, triglycerides, and atherogenic index in blood serum, peak expiratory flow. A high degree of professional conditioning have the frequency of increasing the level of lipid hydroperoxide in blood serum and antioxidant activity of blood plasma.

show abstract

Роль Изменений Окислительно-Восстановительных Реакций В Патогенезе Эндотелиальной Дисфункции Разной Степени Тяжести При Артериальной Гипертонии

Cited by 3 publications

References 2 publications

Antihypertensive Pharmacotherapy in Correcting the Indicators of Innate Immunity in Patients with Essential Arterial Hypertension

Antihypertensive Pharmacotherapy in Correcting the Indicators of Innate Immunity in Patients with Essential Arterial Hypertension

Endothelial function in benign and progressive course of periferal arterial disease

The influence of harmful physical factors and industrial dust on changes in some biochemical and functional indicators of the cardiovascular system and respiratory system in workers engaged in underground mining of ore

Contact Info

Product

Resources

About