Роль Алиментарных Факторов И Пищевой Аллергии В Развитии Псориаза

Барило, А. А.; Смирнова, С. В.

doi:10.24411/0042-8833-2020-10002

Cited by 5 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Существует мнение, что дерматологические заболевания нередко ассоциированы с изменениями в микробиоме желудочно-кишечного тракта, сопровождающимися нарушением барьерной функции слизистой оболочки [3,7]. Пищевые аллергены могут легко проникать через поврежденный желудочно-кишечный барьер и являться триггерами высыпаний на коже [3,8]. Кроме того, повреждение эпидермального барьера при СД может способствовать чреcкожному проникновению аэроаллергенов и сенсибилизации больных.…”

Section: Source Of Financingunclassified

Causal relationship between allergy and seborrheic dermatitis

Барило

Смирнова

2022

Bûll. sib. med.

View full text Add to dashboard Cite

Seborrheic dermatitis is a chronic relapsing inflammatory skin disease associated with overproduction of sebum and activation of the fungal skin microbiota characterized by the presence of erythematous pruritic patches and plaques with greasy scales in areas rich in sebaceous glands.Aim. To study the spectrum of sensitization to food, pollen, and indoor and fungal allergens in patients with seborrheic dermatitis.Materials and methods. The study researched features of the spectrum of sensitization to food, pollen, and fungal and indoor allergens in patients with seborrheic dermatitis (n = 40, aged 15–59 years) based on the data of an objective examination and the results of an allergen-specific test, including skin prick testing.Results. It was determined that the most significant food allergens in seborrheic dermatitis are chicken eggs and grains. The incidence of polyvalent sensitization to food allergens was 40.0%. Additionally, high incidence of sensitization to pollen allergens, most often to weed and poaceae pollen, was revealed in patients with seborrheic dermatitis. Among indoor allergens, the highest incidence of sensitization was determined to house dust and Dermatophagoides pteronyssinus. Among fungal allergens, the highest incidence of sensitization was detected to Candida albicans. Conclusion. It was found that patients with seborrheic dermatitis are often sensitized to food, pollen, and indoor and fungal allergens. Therefore, allergy can be considered a risk factor for the development of pathology.

show abstract

Section: Source Of Financingunclassified

Causal relationship between allergy and seborrheic dermatitis

Барило

Смирнова

2022

Bûll. sib. med.

View full text Add to dashboard Cite

show abstract

Research progress on the neutrophil components and their interactions with immune cells in the development of psoriasis

Wang

Shi

2023

Skin Research and Technology

View full text Add to dashboard Cite

Background: Psoriasis is an immune-mediated chronic inflammatory disease, and currently it is widely believed that the IL-23/IL-17 axis and Th17 cells play a critical and central role. However, increasing evidence suggests that neutrophils may interact with a variety of immune cells to play an indispensable role in psoriasis. Materials and methods:We searched the recent literature on psoriasis and neutrophils through databases such as PubMed and CNKI, and summarized the findings to draw conclusions. Results: Neutrophils can promote the development of psoriasis by secreting IL-23, IL-17, and cytokines with TH17 cell chemotaxis. Activated keratinocytes (KCs) can attract and activate neutrophils, induce the formation of neutrophil extracellular traps (NETs).KCs can also expose self-antigens which lead to strong autoimmune reactions. The granule proteins secreted by activated neutrophils can activate IL-36, which converts vulgaris psoriasis to generalized pustular psoriasis (GPP). Conclusion:The function of neutrophils components and the interaction between neutrophils and immune cells play an essential role in the pathogenesis of psoriasis. The aim is to provide a theoretical basis for the exploration of targeted clinical treatments and fundamental research on the pathogenesis of psoriasis.

show abstract

Fungal allergy as a risk factor for developing rosacea

Barilo,

Smirnova

2023

Russian Journal of Infection and Immunity

View full text Add to dashboard Cite

The pathogenesis of rosacea is not fully understood. In this disease, the release of inflammatory molecules and overgrowth of skin-colonizing microorganisms, including fungal microbiota, are noted. The study of the frequency of occurrence and the nature of the spectrum of sensitization to fungal allergens in patients with rosacea is of particular interest and accounts for relevance of the study. Purpose of the study: to analyze the frequency of occurrence and the nature of the spectrum of sensitization to fungal allergens in patients with rosacea. Materials and methods. The study included patients with rosacea aged 18 to 60 years (group 1, n = 31). All patients underwent a specific allergic examination: collected allergic history, skin prick testing using the following allergens: nutritional yeast, Candida albicans, Alternaria alternate, Aspergillus fumigatus, Cladosporium herbarum, Penicillium notatum (Allergopharma, Germany). Concentration of total immunoglobulin E (IgE) and eosinophilic cationic protein in blood serum was measured in indirect immunofluorescence analysis with Thermo Scientific Multiskan FC semi-automatic analyzer. Statistica 8.0 software package was used for statistical analysis. Results. Analysis of the features of the spectrum of sensitization to fungal allergens in the group of patients with rosacea showed that the most significant allergens are Cladosporium herbarum (74.2% of patients) and Candida albicans (58.1%). Sensitization to nutritional yeast and Penicillium notatum was detected in almost half of the patients. The concentration of total immunoglobulin E in blood serum in the group of patients with rosacea was 79.4 IU/ml [23.4; 105.1], in the control group 45.1 IU/ml [23.4; 144.0]. The concentration of eosinophilic cationic protein in blood serum in the group of patients with rosacea was significantly higher compared to the control group: 50.3 ng/ml [43.0; 62.0] and 7.9 ng/ml [4.6; 27.1], respectively. After skin prick testing with fungal allergens, patients with rosacea were prescribed an individual elimination diet with the exclusion of causally significant allergens for a period of 1 month. In 61.2% (n = 19) of cases in patients with rosacea, a positive elimination effect was noted: a significant decrease in the severity of erythema, papules and pustules in the face. Conclusion. Thus, the study revealed a high incidence of fungal allergy and established the features of the spectrum of sensitization to fungal allergens in patients with rosacea. The most significant fungal allergens in rosacea are fungi of the genus Cladosporium herbarum, Candida albicans, Penicillium notatum as well as nutritional yeast.

show abstract

Роль Алиментарных Факторов И Пищевой Аллергии В Развитии Псориаза

Cited by 5 publications

References 0 publications

Causal relationship between allergy and seborrheic dermatitis

Causal relationship between allergy and seborrheic dermatitis

Research progress on the neutrophil components and their interactions with immune cells in the development of psoriasis

Fungal allergy as a risk factor for developing rosacea

Contact Info

Product

Resources

About