Роль Адипокинов В Формировании Кардиометаболических Нарушений У Человека

Alferova, V. I.; Мустафина, С. В.

doi:10.52727/2078-256x-2022-18-4-388-394

Атеросклероз

2023

DOI: 10.52727/2078-256x-2022-18-4-388-394

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Роль Адипокинов В Формировании Кардиометаболических Нарушений У Человека

V. I. Alferova¹,

С. В. Мустафина²

Abstract: В обзоре представлены результаты исследований возможных механизмов, посредством которых реализуется влияние адипокинов на сердечно-сосудистую систему. Проанализированы такие адипокины и цитокины, как адипонектин, лептин, резистин, адипсин, интерлейкин-6, фактор некроза опухоли α. Приводятся данные о патогенетических и клинических особенностях выработки данных биологически активных веществ и их влияния на метаболизм. Проанализированы тематические источники из баз данных PubMed, РИНЦ.

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Cited by 2 publications

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References 36 publications

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“…Клиническая и экспериментальная тиреоидология 2022;18(3):[13][14][15][16][17][18][19][20][21][22] Clinical and experimental thyroidology. 2022;18(3):13-22 doi: https://doi.org/10.14341/ket12725…”

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Association of thyroidstimulating hormone, prolactin and leptin with metabolic status in young women 25-44 years old in Western Siberia

et al. 2023

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AIM: To study anthropometric, biochemical and hormonal characteristics of women aged 25-44 with different levels of thyroid- stimulating hormone, prolactin and leptin.MATERIALS AND METHODS: From a representative sample of the young population of the Oktyabrsky district of Novosibirsk aged 25-44 years (840 women), a group of women (n=655) was selected to study cardiometabolic and hormonal parameters. The design of the study was a cross-sectional, observational, single-centre study. All participants underwent determination of anthropometric parameters (weight, measurement of waist circumference (WC) and hips (HC), calculation of BMI), systolic and diastolic blood pressure (SBP, DBP), biochemical parameters (total cholesterol (TC), high-density lipoprotein cholesterol ( HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), fasting plasma glucose (FPG), creatinine, calculation of glomerular filtration rate (GFR).Statistical processing was carried out using the SPSS-13 package.RESULTS: The study included 655 women, mean age 36.3±5.4 years, mean BMI 25.0±5.7 kg/m2. Young women showed direct associations of TSH with HC (r=0.115, p<0.05), TG (r=0.145, p<0.010) and inverse association with GFR (r=-0.129, p<0.05). PRL is inversely associated with HC (r=-0.109, p<0.05). Of all the studied hormones, leptin is most associated with anthropometric and biochemical parameters in young women. Thus, leptin is directly associated with WC (r=0.562, p<0.0001), HC (r=0.589, p<0.0001), WC/HC index (r=0.309, p<0.0001), BMI ( r=0.582, p<0.0001), as well as levels of SBP (r=0.293, p<0.0001), DBP (r=0.274, p<0.0001), TC (r=0.123, p=0.018), TG (r=0.234, p<0.0001), FPG (r=0.150, p=0.004), inversely related to HDL-C (r=-0.225, p<0.0001).CONCLUSION: The metabolic status of women aged 25-44 is associated with the level of TSH, leptin. It is advisable to determine TSH, leptin in young women with abdominal obesity for the purpose of dynamic monitoring and correction.

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Association of thyroidstimulating hormone, prolactin and leptin with metabolic status in young women 25-44 years old in Western Siberia

et al. 2023

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A new aspect of metabolic disorders in obesity: carbonyl stress

Lesnaya,

Darenskaya,

Semenova

et al. 2024

Sibirskij nauchnyj medicinskij zhurnal

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The literature review examines the problem of obesity in modern society. It has been shown that obesity aggravates concomitant diseases, increases the probability of developing metabolic disorders and related pathologies, increases the risk of complications and mortality. The secretory function of adipose tissue, its participation in the regulation of biological processes is considered in detail. The concept of carbonyl stress and its components is revealed, the role of carbonyl compounds in the body is described, the metabolic pathways leading to the formation of carbonyl reaction products are shown, the participation of free radicals in these metabolic pathways is noted. The mechanisms of pathogenesis associated with the development of carbonyl stress in obesity are discussed; the greatest contribution to the development of car bonyl pathology in obesity is made by two types of processes: lipid peroxidation reactions resulting in the formation of carbonyl products of lipoperoxidation and the processes activated by hyperglycemia (glycolysis, polyol and hexоzamine pathways) leading to the formation of glyoxal, methylglyoxal, and active carbonyl forms of glucose. The question of the contribution of advanced glycation end products (AGEs) and advanced oxidation protein products (AOРР) to the development of carbonyl pathology in obesity remains controversial. It is assumed that AGEs and AOРР levels depend on the severity of obesity and the development of metabolic syndrome.

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Роль Адипокинов В Формировании Кардиометаболических Нарушений У Человека

Cited by 2 publications

References 36 publications

Association of thyroidstimulating hormone, prolactin and leptin with metabolic status in young women 25-44 years old in Western Siberia

Association of thyroidstimulating hormone, prolactin and leptin with metabolic status in young women 25-44 years old in Western Siberia

A new aspect of metabolic disorders in obesity: carbonyl stress

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