Рhosprenyl and gamavit augment treatment efficacy of household poisoning in cats

Pereslegina, Pereslegina; Dubrovina, T.S.; Klintzova, T.Yu; Agafonova, Aleksandra; Zotova, S.N.

doi:10.30917/att-vk-1814-9588-2018-1-10

Cited by 2 publications

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“…Гамавит применяют в ветеринарии для повышения резистентности организма [2,5], коррекции анемии [4,9,17,21], детоксикации при отравлениях [7,11,13,14,19], восстановления биохимических параметров крови при паразитарных инвазиях [1,6,8,10,12,16,18] и при иной патологии [2,3,20]. Для лучшего понимания особенностей эффективного применения гамавита ветеринарному врачу необходима информация о фармакокинетических характеристиках препарата.…”

Section: Introductionunclassified

Study of the parameters of absorption into the bloodstream and excretion of the drug Gamavit after a single administration to laboratory mini-pigs

Narovlyanskiy

Санин

Смирнов

et al. 2021

Russian Veterinary Journal

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A pharmacokinetic study of the absorption into the bloodstream, bioavailability and excretion of Gamavit from the body after intramuscular administration to laboratory mini-pigs was conducted. Quantitative determination was carried out by HPLC using a fluorimetric detector, for which Gamavit was labeled with Cy5 dye, which was then used for mini-pigs inoculation. The developed methods for determining Gamavit in the blood and feces were validated according to the following validation parameters: selectivity, calibration curve, accuracy, precision, limit of quantitative determination, sample transfer, and sample stability. The confirmed analytical range of the method for Gamavit detection in blood plasma and feces was 1.00…50.0 mcg/ml. Maximum concentration of Gamavit in the blood of mini-pigs after a single intramuscular injection was 30.97 mcg/ml and was reached on average 15 minutes after administration. 24 hours following administration, Gamavit was still detected in the blood in insignificant amounts. The average half-life of Gamavit in the blood is 8.64±3.50 hours. After administration at a dose of 0.1 ml/kg, the clearance of the drug is 1.27 l/kg * h, the excretion rate at an effective concentration of 30 mg/l is 38 mg/kg*h, and the maintenance dose when using the drug 1 time a day is 0.9…1.0 ml. The detection of the label in the feces of the studied animals indicates that one of the ways Gamavit removal is excretion with the help of bile acids, as well as partial excretion with feces.

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Section: Introductionunclassified

Study of the parameters of absorption into the bloodstream and excretion of the drug Gamavit after a single administration to laboratory mini-pigs

Narovlyanskiy

Санин

Смирнов

et al. 2021

Russian Veterinary Journal

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Supplementation of feline hemoplasmosis treatment protocol with Gamavit and Phosprenyl increases the effectiveness of anemia correction: a retrospective analysis

Savoyskaya

2024

Russian Veterinary Journal

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This study includes clinical data collected from 2016 to 2023. In total, hemoplasmosis was detected in 102 cats (63 females and 39 males) aged from 5 months to 8 years. Of these, 34 cats were diagnosed with a severe form of the disease, and 68 with a mild one. In cats with severe hemoplasmosis, in 45 % of cases, the disease was complicated by chronic renal failure. Also, 5 % of them were chronic carriers of toxoplasmas. Most of the animals were taken from shelters, or were homeless. One of the leading clinical signs of hemoplasmosis is anemia, which develops as a result of mass hemolysis of infected red blood cells. The aim of this work was to eliminate anemia and accelerate the normalization of hematopoiesis in cats with hemoplasmosis. For the treatment of 45 animals (control group), a standard therapy regimen was used, which included antibiotics and glucocorticoids, whereas for therapy regimen of remaining 57 cats (experimental group) Gamavit and Phosprenyl were added. Using this therapeutic scheme, early relief of anemia, stimulation of erythropoiesis, restoration of blood formula and normalization of liver function were noted as well as acceleration of clinical recovery of sick animals which occurred faster by 4…5 days.

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Рhosprenyl and gamavit augment treatment efficacy of household poisoning in cats

Cited by 2 publications

References 0 publications

Study of the parameters of absorption into the bloodstream and excretion of the drug Gamavit after a single administration to laboratory mini-pigs

Study of the parameters of absorption into the bloodstream and excretion of the drug Gamavit after a single administration to laboratory mini-pigs

Supplementation of feline hemoplasmosis treatment protocol with Gamavit and Phosprenyl increases the effectiveness of anemia correction: a retrospective analysis

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