Objective. To evaluate the quality of life in patients with advanced/recurrent melanoma receiving immunotherapy with checkpoint inhibitors. Material and methods. The study enrolled 30 patients with advanced/recurrent melanoma treated with checkpoint inhibitors in the City Clinical Oncology Center, Saint Petersburg from 2020 to 2023. Quality of life was measured by SF-36 questionnaire and ESAS-R scale thrice: before treatment, after one and three months. Results. The age of the included patients ranged from 30 to 87 years (mean age is 64 ± 11 years, 95% CI 57.20–71.11). Cutaneous melanoma was present in 90% of the patients, while melanoma of mucosal origin was found in 10% of the patients. The functional status of 40% of the patients on the ECOG scale was 2–3 points. 40% (n = 12) of patients received Prolgolimab, 26.7% (n = 8) received the combination of Nivolumab 1 mg/kg + Ipilimumab 3 mg/kg, 23.3% (n = 7) received Nivolumab in mono regimen, 6.7% (n = 2) received Ipilimumab, and 3.3% (n = 1) received the combination Nivolumab 3 mg/kg + Ipilimumab 1 mg/kg. There was a significant decrease in pain (before treatment 2.29 ± 1.979, after 3 months 1.29 ± 1.922 (p = 0.021)), an improvement in the overall symptom profile (before treatment 15.79 ± 11.127, after 1 month – 12.00 ± 8.899, after 3 months – 12.82 ± 12.157 (p = 0.006)) on ESAS-R questionnaire was registered. Improvement was noted in most scales of the SF-36 questionnaire compared with baseline, with statistically significant changes obtained for physical functioning (p = 0.05), pain (p = 0.01), social functioning (p = 0.013), mental health (p = 0.01), overall index of physical health component (p = 0.001), overall index of mental health component (p = 0.042). Conclusion. The results demonstrate a positive effect of treatment with checkpoint inhibitors on the quality of life and symptom profile of patients diagnosed with advanced/recurrent melanoma.