Практические Рекомендации По Лечению Рака Анального Канала И Кожи Перианальной Области

Гордеев, С. С.; Бесова, Н. С.; Глебовская, В. В.; Горбунова, В. А.; Мамедли, З. З.; Ткачев, С. И.; Федянин, М. Ю.; Черных, М. В.

doi:10.18027/2224-5057-2020-10-3s2-24

Cited by 4 publications

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“…При исследовании вирусной нагрузки ВПЧ 16 выявлено, что она была выше в группе больных, ранее не получавших лечения [19]. Установлено, что ВПЧ-позитивность была связана с лучшей выживаемостью и ответом на химио лучевую терапию (подобно плоскоклеточному раку головы и шеи), а низкая вирусная нагрузка была прогностическим фактором более низкой общей выживаемости [1,17].…”

Section: Introductionunclassified

Detection of human papillomavirus, viral load and risk factors in patients with precancerous diseases and malignant neoplasms in St. Petersburg

Kholopov

Vyazovaya

Топузов

et al. 2022

Russian Journal of Infection and Immunity

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Molecular genetic studies have revealed the involvement of different genotypes of human papillomavirus (HPV) in the carcinogenesis of cervical cancer and malignant lesions of other localizations. It is reported that patients with HPV-positive cancer have a better prognosis of the disease and survival than patients with unconfirmed HPV infection or with a low viral load. The objective was to identify the detectability, viral load, genotypes of human papillomavirus in HPV-associated precancerous and malignant neoplasia of various localization and to determine risk factors for their occurrence in the metropolis of St. Petersburg at the present time. Materials and methods. A total of 80 samples taken from morphologically confirmed tissues of oropharyngeal and anal cancer, malignant tumors of vulva, vagina, cervix and cervical intraepithelial neoplasia were studied in St. Petersburg Clinical Oncologic Center. Detection, quantification and genotyping of HPV DNA were carried out by real-time PCR at the St. Petersburg Pasteur Institute. Results. HPV was detected in 89.7% (61/68) of patients with malignant tumors and 83.3% (10/12) with severe cervical dysplasia. The vast majority (85.9%) of HPV-positive patients were infected with HPV genotype 16; papillomavirus mixed infection (genotypes 16, 18, 31, 33, 35, 39, 45) was detected in anal cancer, cancer and severe cervical dysplasia. The average viral load in stages IIIIV of anal cancer, cervical cancer and severe cervical dysplasia exceeded 5.7 lg HPV DNA/105 cells. Among patients with oropharyngeal cancer, men predominated (85.7%); anal cancer was detected in women (90.0%). No statistically significant risk factors (smoking and alcohol consumption) for the occurrence of HPV-associated malignancies were identified. Conclusions. The detection of HPV, mainly of genotype 16, varied depending on the location of the neoplasia: anal cancer 100%, cancer of the female genitalia 94% (in case of cancer of the vagina and cervix 100.0%), head and neck cancer 76.2%. The highest HPV DNA load in the tumor tissue was found in IIIIV stages of the cervical and anal cancer.

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Section: Introductionunclassified

Detection of human papillomavirus, viral load and risk factors in patients with precancerous diseases and malignant neoplasms in St. Petersburg

Kholopov

Vyazovaya

Топузов

et al. 2022

Russian Journal of Infection and Immunity

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Surgical treatment of late radiation injury of the soft tissues of the sacrococcygeal and perineal areas caused by combination treatment of the anal canal (clinical observation)

Grigoriev

Пасов

Korotkov

et al. 2022

Androl. genit. hir.

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Химиолучевое лечение пациентов с раком анального канала является основным при I-II стадиях развития онкологического заболевания. У части пациентов после лучевой терапии возникают поздние лучевые повреждения мягких тканей. В статье представлен клинический случай успешного хирургического лечения обширного постлучевого фиброза и язвы мягких тканей перианальной области.Ключевые слова: рак анального канала, лучевая терапия, осложнения, лучевые повреждения мягких тканей, хирургическое лечение Для цитирования: Григорьев Н.С., Пасов В.В., Коротков В.А. и др. Хирургическое лечение поздних лучевых повреждений мягких тканей крестцово-копчиковой и перианальной областей, сформировавшихся в результате комплексного лечения рака анального канала (клиническое наблюдение).

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Evaluation of effectiveness of combined supportive treatment for paronychia and pyogenic granulomas, associated with targeted anticancer therapy

Polonskaya

Шатохина

Круглова

2023

Russian Journal of Skin and Venereal Diseases

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BACKGROUND: Paronychia and pyogenic granulomas occur in 1050% of patients treated with epidermal growth receptor (EGFR) inhibitors. Supportive therapy for periungual lesions is challenging, since these adverse reactions are prone to torpidity and frequent relapses. AIM: to evaluate the effectiveness of supportive treatment for paronychia and pyogenic granulomas ― dermatologic adverse events of EGFR inhibitors, with a combined cream with betamethasone dipropionate, clotrimazole, gentamicin, and betaxolol solution. MATERIALS AND METHODS: 16 patients with paronychia and pyogenic granulomas associated with EGFR inhibitor therapy were included in a 12-week open-label prospective study. Paronychia and pyogenic granulomas severity assessment was performed with the NCI-CTCAE v. 5.0, a developed 10-point scale. The intensity of pain was assessed with a visual-analogue scale (VAS). The quality of life was assessed with the Dermatology Life Quality Index (DLQI). RESULTS: A significant improvement of all parameters (p 0.05) was evaluated from week 1, indicating the effective reduction of dermatologic adverse event objective and subjective symptoms, improvement of patients quality of life. By the end of the study, 37.5% of patients had complete resolution of lesions, 62.5% of patients had minimal residual erythema. Decrease of pain sensation in the affected periungual folds was observed throughout the study (p 0.05). DLQI score indicated the "small effect" of paronychia and pyogenic granulomas on patients life by the end of the study. CONCLUSIONS: Supportive treatment of paronychia and pyogenic granulomas with a combined cream with betamethasone dipropionate, clotrimazole and gentamicin and a betaxolol 0.25% solution is effective in the management of paronychia and pyogenic granulomas objective and subjective symptoms, has a high tolerability, allows to improve patients quality of life and continue targeted therapy without dose reduction. Long-term maintenance of pain sensation after paronychia and pyogenic granulomas resolution underlines the need for additional treatment options that will improve the effectiveness of pain management.

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Практические Рекомендации По Лечению Рака Анального Канала И Кожи Перианальной Области

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Cited by 4 publications

References 0 publications

Detection of human papillomavirus, viral load and risk factors in patients with precancerous diseases and malignant neoplasms in St. Petersburg

Detection of human papillomavirus, viral load and risk factors in patients with precancerous diseases and malignant neoplasms in St. Petersburg

Surgical treatment of late radiation injury of the soft tissues of the sacrococcygeal and perineal areas caused by combination treatment of the anal canal (clinical observation)

Evaluation of effectiveness of combined supportive treatment for paronychia and pyogenic granulomas, associated with targeted anticancer therapy

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